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Mapping the effect of the apolipoprotein E genotype on 4-year atrophy rates in an Alzheimer disease-related brain network.

Publication ,  Journal Article
Hostage, CA; Choudhury, KR; Murali Doraiswamy, P; Petrella, JR; Alzheimer's Disease Neuroimaging Initiative,
Published in: Radiology
April 2014

PURPOSE: To determine the effect of the apolipoprotein E (APOE) genotype on atrophy rates of specific brain gray matter regions hypothesized to be key components of cognitive networks disrupted in Alzheimer disease. MATERIALS AND METHODS: The Alzheimer's Disease Neuroimaging Initiative (ADNI) was approved by the institutional review boards of all participating sites. All subjects and their legal representatives gave written informed consent prior to data collection. The authors analyzed data from 237 subjects (mean age, 79.9 years; 40% female) with mild cognitive impairment (MCI) in the ADNI database and assessed the effect of the APOE ε4 and ε2 alleles on regional brain atrophy rates over a 12-48-month period. Brain regions were selected a priori: 15 experimental and five control regions were included. Regional atrophy rates were derived by using a fully automated algorithm applied to T1-weighted magnetic resonance (MR) imaging data. Analysis consisted of mixed-effects linear regression with repeated measures; results were adjusted for multiple testing with Bonferroni correction. RESULTS: Thirteen of 15 experimental regions showed a significant effect of ε4 for higher atrophy rates (P < .001 for all). Cohen d values ranged from 0.26 to 0.42, with the largest effects seen in the amygdalae and hippocampi. The transverse temporal cortex showed a trend (P = .02, but did not survive Bonferroni correction) for a protective effect (Cohen d value = 0.15) of ε2. No control region showed an APOE effect. CONCLUSION: The APOE ε4 allele is associated with accelerated rates of atrophy in 13 distinct brain regions in limbic and neocortical areas. This suggests the possibility of a genotype-specific network of related brain regions that undergo faster atrophy in MCI and potentially contribute to cognitive decline. Online supplemental material is available for this article.

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Published In

Radiology

DOI

EISSN

1527-1315

Publication Date

April 2014

Volume

271

Issue

1

Start / End Page

211 / 219

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Neuropsychological Tests
  • Neuroimaging
  • Models, Statistical
  • Male
  • Longitudinal Studies
  • Image Interpretation, Computer-Assisted
  • Humans
  • Genotype
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Hostage, C. A., Choudhury, K. R., Murali Doraiswamy, P., Petrella, J. R., & Alzheimer’s Disease Neuroimaging Initiative, . (2014). Mapping the effect of the apolipoprotein E genotype on 4-year atrophy rates in an Alzheimer disease-related brain network. Radiology, 271(1), 211–219. https://doi.org/10.1148/radiol.13131041
Hostage, Christopher A., Kingshuk Roy Choudhury, P. Murali Doraiswamy, Jeffrey R. Petrella, and Jeffrey R. Alzheimer’s Disease Neuroimaging Initiative. “Mapping the effect of the apolipoprotein E genotype on 4-year atrophy rates in an Alzheimer disease-related brain network.Radiology 271, no. 1 (April 2014): 211–19. https://doi.org/10.1148/radiol.13131041.
Hostage CA, Choudhury KR, Murali Doraiswamy P, Petrella JR, Alzheimer’s Disease Neuroimaging Initiative. Mapping the effect of the apolipoprotein E genotype on 4-year atrophy rates in an Alzheimer disease-related brain network. Radiology. 2014 Apr;271(1):211–9.
Hostage, Christopher A., et al. “Mapping the effect of the apolipoprotein E genotype on 4-year atrophy rates in an Alzheimer disease-related brain network.Radiology, vol. 271, no. 1, Apr. 2014, pp. 211–19. Pubmed, doi:10.1148/radiol.13131041.
Hostage CA, Choudhury KR, Murali Doraiswamy P, Petrella JR, Alzheimer’s Disease Neuroimaging Initiative. Mapping the effect of the apolipoprotein E genotype on 4-year atrophy rates in an Alzheimer disease-related brain network. Radiology. 2014 Apr;271(1):211–219.

Published In

Radiology

DOI

EISSN

1527-1315

Publication Date

April 2014

Volume

271

Issue

1

Start / End Page

211 / 219

Location

United States

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • Neuropsychological Tests
  • Neuroimaging
  • Models, Statistical
  • Male
  • Longitudinal Studies
  • Image Interpretation, Computer-Assisted
  • Humans
  • Genotype
  • Female