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Impairment of kindling development in phospholipase Cγ1 heterozygous mice.

Publication ,  Journal Article
He, XP; Wen, R; McNamara, JO
Published in: Epilepsia
March 2014

OBJECTIVE: Elucidating molecular mechanisms underlying limbic epileptogenesis may reveal novel targets for preventive therapy. Studies of TrkB mutant mice led us to hypothesize that signaling through a specific phospholipase (PLC), PLCγ1, promoted development of kindling. METHODS: To test this hypothesis, we examined the development of kindling in PLCγ1 heterozygous mice. We also examined the cellular and subcellular location of PLCγ1 in adult wild-type mice. RESULTS: The development of kindling was impaired in PLCγ1 heterozygous mice compared to wild-type controls. PLCγ1 immunoreactivity was localized to the soma and dendrites of both excitatory and inhibitory neurons in the hippocampus of adult mice. SIGNIFICANCE: This study implicates PLCγ1 signaling as the dominant pathway by which TrkB activation promotes limbic epileptogenesis. Its cellular localization places PLCγ1 in a position to modify the efficacy of both excitatory and inhibitory synaptic transmission. These findings advance PLCγ1 as a novel target for therapies aimed at preventing temporal lobe epilepsy induced by status epilepticus.

Duke Scholars

Published In

Epilepsia

DOI

EISSN

1528-1167

Publication Date

March 2014

Volume

55

Issue

3

Start / End Page

456 / 463

Location

United States

Related Subject Headings

  • Signal Transduction
  • Seizures
  • Phospholipase C gamma
  • Neurology & Neurosurgery
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice, 129 Strain
  • Mice
  • Kindling, Neurologic
  • Hippocampus
 

Citation

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He, X. P., Wen, R., & McNamara, J. O. (2014). Impairment of kindling development in phospholipase Cγ1 heterozygous mice. Epilepsia, 55(3), 456–463. https://doi.org/10.1111/epi.12536
He, Xiao Ping, Renren Wen, and James O. McNamara. “Impairment of kindling development in phospholipase Cγ1 heterozygous mice.Epilepsia 55, no. 3 (March 2014): 456–63. https://doi.org/10.1111/epi.12536.
He XP, Wen R, McNamara JO. Impairment of kindling development in phospholipase Cγ1 heterozygous mice. Epilepsia. 2014 Mar;55(3):456–63.
He, Xiao Ping, et al. “Impairment of kindling development in phospholipase Cγ1 heterozygous mice.Epilepsia, vol. 55, no. 3, Mar. 2014, pp. 456–63. Pubmed, doi:10.1111/epi.12536.
He XP, Wen R, McNamara JO. Impairment of kindling development in phospholipase Cγ1 heterozygous mice. Epilepsia. 2014 Mar;55(3):456–463.
Journal cover image

Published In

Epilepsia

DOI

EISSN

1528-1167

Publication Date

March 2014

Volume

55

Issue

3

Start / End Page

456 / 463

Location

United States

Related Subject Headings

  • Signal Transduction
  • Seizures
  • Phospholipase C gamma
  • Neurology & Neurosurgery
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice, 129 Strain
  • Mice
  • Kindling, Neurologic
  • Hippocampus