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Two novel PRKCI polymorphisms and prostate cancer risk in an Eastern Chinese Han population.

Publication ,  Journal Article
Li, Q; Gu, C; Zhu, Y; Wang, M; Yang, Y; Wang, J; Jin, L; Zhu, M-L; Shi, T-Y; He, J; Ye, D; Wei, Q
Published in: Mol Carcinog
August 2015

The atypical protein kinase C (aPKCι), encoded by the PRKCI gene, has been recently found to be a unique human oncoprotein, compared with some other diverse PKC isozymes. Genetic variations in PRKCI have also been reported to be associated with prostate cancer (PCa) risk in Caucasian populations, but no similar studies have been reported for Chinese populations. We genotyped two well-described PRKCI single nucleotide polymorphisms (SNPs) rs546950 and rs4955720 in 1015 PCa patients and 1044 cancer-free controls of Eastern Chinese men. SNPs in the vicinity of those two variants of PRKCI were evaluated using the in silico analysis. Logistic regression was then used to estimate their associations with and interactions in PCa risk. Although no significant main effects were found for the two tested SNPs in the single locus analysis, individuals carrying homozygote wide-type form of these two SNPs had slightly reduced PCa risk (adjusted OR = 0.63, 95% CI = 0.40-0.99, P = 0.045), compared with those carrying any of heterozygous or homozygous variant genotypes. Our results indicated that the two PRKCI SNPs were jointly associated with PCa risk in an Eastern Chinese population. Larger studies with multiethnic groups are warranted to confirm these findings and to explore the role of PRKCI SNPs in the etiology of PCa.

Duke Scholars

Published In

Mol Carcinog

DOI

EISSN

1098-2744

Publication Date

August 2015

Volume

54

Issue

8

Start / End Page

632 / 641

Location

United States

Related Subject Headings

  • Protein Kinase C
  • Prostatic Neoplasms
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Isoenzymes
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
 

Citation

APA
Chicago
ICMJE
MLA
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Li, Q., Gu, C., Zhu, Y., Wang, M., Yang, Y., Wang, J., … Wei, Q. (2015). Two novel PRKCI polymorphisms and prostate cancer risk in an Eastern Chinese Han population. Mol Carcinog, 54(8), 632–641. https://doi.org/10.1002/mc.22130
Li, Qiaoxin, Chengyuan Gu, Yao Zhu, Mengyun Wang, Yajun Yang, Jiucun Wang, Li Jin, et al. “Two novel PRKCI polymorphisms and prostate cancer risk in an Eastern Chinese Han population.Mol Carcinog 54, no. 8 (August 2015): 632–41. https://doi.org/10.1002/mc.22130.
Li Q, Gu C, Zhu Y, Wang M, Yang Y, Wang J, et al. Two novel PRKCI polymorphisms and prostate cancer risk in an Eastern Chinese Han population. Mol Carcinog. 2015 Aug;54(8):632–41.
Li, Qiaoxin, et al. “Two novel PRKCI polymorphisms and prostate cancer risk in an Eastern Chinese Han population.Mol Carcinog, vol. 54, no. 8, Aug. 2015, pp. 632–41. Pubmed, doi:10.1002/mc.22130.
Li Q, Gu C, Zhu Y, Wang M, Yang Y, Wang J, Jin L, Zhu M-L, Shi T-Y, He J, Ye D, Wei Q. Two novel PRKCI polymorphisms and prostate cancer risk in an Eastern Chinese Han population. Mol Carcinog. 2015 Aug;54(8):632–641.
Journal cover image

Published In

Mol Carcinog

DOI

EISSN

1098-2744

Publication Date

August 2015

Volume

54

Issue

8

Start / End Page

632 / 641

Location

United States

Related Subject Headings

  • Protein Kinase C
  • Prostatic Neoplasms
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Isoenzymes
  • Humans
  • Genotype
  • Genetic Predisposition to Disease