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Neural correlates of cognitive and affective processing in maltreated youth with posttraumatic stress symptoms: does gender matter?

Publication ,  Journal Article
Crozier, JC; Wang, L; Huettel, SA; De Bellis, MD
Published in: Dev Psychopathol
May 2014

We investigated the relationship of gender to cognitive and affective processing in maltreated youth with posttraumatic stress disorder symptoms using functional magnetic resonance imaging. Maltreated (N = 29, 13 females, 16 males) and nonmaltreated participants (N = 45, 26 females, 19 males) performed an emotional oddball task that involved detection of targets with fear or scrambled face distractors. Results were moderated by gender. During the executive component of this task, left precuneus/posterior middle cingulate hypoactivation to fear versus calm or scrambled face targets were seen in maltreated versus control males and may represent dysfunction and less resilience in attentional networks. Maltreated males also showed decreased activation in the inferior frontal gyrus compared to control males. No differences were found in females. Posterior cingulate activations positively correlated with posttraumatic stress disorder symptoms. While viewing fear faces, maltreated females exhibited decreased activity in the dorsomedial prefrontal cortex and cerebellum I-VI, whereas maltreated males exhibited increased activity in the left hippocampus, fusiform cortex, right cerebellar crus I, and visual cortex compared to their same-gender controls. Gender by maltreatment effects were not attributable to demographic, clinical, or maltreatment parameters. Maltreated girls and boys exhibited distinct patterns of neural activations during executive and affective processing, a new finding in the maltreatment literature.

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Published In

Dev Psychopathol

DOI

EISSN

1469-2198

Publication Date

May 2014

Volume

26

Issue

2

Start / End Page

491 / 513

Location

United States

Related Subject Headings

  • Visual Cortex
  • Stress Disorders, Post-Traumatic
  • Sex Factors
  • Prefrontal Cortex
  • Neuroimaging
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Gyrus Cinguli
  • Female
 

Citation

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Crozier, J. C., Wang, L., Huettel, S. A., & De Bellis, M. D. (2014). Neural correlates of cognitive and affective processing in maltreated youth with posttraumatic stress symptoms: does gender matter? Dev Psychopathol, 26(2), 491–513. https://doi.org/10.1017/S095457941400008X
Crozier, Joseph C., Lihong Wang, Scott A. Huettel, and Michael D. De Bellis. “Neural correlates of cognitive and affective processing in maltreated youth with posttraumatic stress symptoms: does gender matter?Dev Psychopathol 26, no. 2 (May 2014): 491–513. https://doi.org/10.1017/S095457941400008X.
Crozier JC, Wang L, Huettel SA, De Bellis MD. Neural correlates of cognitive and affective processing in maltreated youth with posttraumatic stress symptoms: does gender matter? Dev Psychopathol. 2014 May;26(2):491–513.
Crozier, Joseph C., et al. “Neural correlates of cognitive and affective processing in maltreated youth with posttraumatic stress symptoms: does gender matter?Dev Psychopathol, vol. 26, no. 2, May 2014, pp. 491–513. Pubmed, doi:10.1017/S095457941400008X.
Crozier JC, Wang L, Huettel SA, De Bellis MD. Neural correlates of cognitive and affective processing in maltreated youth with posttraumatic stress symptoms: does gender matter? Dev Psychopathol. 2014 May;26(2):491–513.
Journal cover image

Published In

Dev Psychopathol

DOI

EISSN

1469-2198

Publication Date

May 2014

Volume

26

Issue

2

Start / End Page

491 / 513

Location

United States

Related Subject Headings

  • Visual Cortex
  • Stress Disorders, Post-Traumatic
  • Sex Factors
  • Prefrontal Cortex
  • Neuroimaging
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Gyrus Cinguli
  • Female