Skip to main content

The role of complement dysregulation in AMD mouse models.

Publication ,  Journal Article
Ding, J-D; Kelly, U; Groelle, M; Christenbury, JG; Zhang, W; Bowes Rickman, C
Published in: Adv Exp Med Biol
2014

Variations in several complement genes are now known to be significant risk factors for the development of age-related macular degeneration (AMD). Despite dramatic effects on disease susceptibility, the underlying mechanisms by which common polymorphisms in complement proteins alter disease risk have remained unclear. Genetically modified mice in which the activity of the complement has been altered are available and can be used to investigate the role of complement in the pathogenesis of AMD. In this mini review, we will discuss some existing complement models of AMD and our efforts to develop and characterize the ocular phenotype in a variety of mice in which complement is either chronically activated or inhibited. A spectrum of complement dysregulation was modeled on the APOE4 AMD mouse model by crossing these mice to complement factor H knockout (cfh-/-) mice to test the impact of excess complement activation, and by crossing them to soluble-complement-receptor-1-related protein y (sCrry) mice, in which sCrry acts as a potent inhibitor of mouse complement acting in a manner similar to CFH. In addition, we have also generated humanized CFH mice expressing normal and risk variants of CFH.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Adv Exp Med Biol

DOI

ISSN

0065-2598

Publication Date

2014

Volume

801

Start / End Page

213 / 219

Location

United States

Related Subject Headings

  • Mice, Knockout
  • Mice
  • Macular Degeneration
  • Kidney Diseases
  • Humans
  • Hereditary Complement Deficiency Diseases
  • General & Internal Medicine
  • Disease Models, Animal
  • Complement System Proteins
  • Complement Factor H
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ding, J.-D., Kelly, U., Groelle, M., Christenbury, J. G., Zhang, W., & Bowes Rickman, C. (2014). The role of complement dysregulation in AMD mouse models. Adv Exp Med Biol, 801, 213–219. https://doi.org/10.1007/978-1-4614-3209-8_28
Ding, Jin-Dong, Una Kelly, Marybeth Groelle, Joseph G. Christenbury, Wenlan Zhang, and Catherine Bowes Rickman. “The role of complement dysregulation in AMD mouse models.Adv Exp Med Biol 801 (2014): 213–19. https://doi.org/10.1007/978-1-4614-3209-8_28.
Ding J-D, Kelly U, Groelle M, Christenbury JG, Zhang W, Bowes Rickman C. The role of complement dysregulation in AMD mouse models. Adv Exp Med Biol. 2014;801:213–9.
Ding, Jin-Dong, et al. “The role of complement dysregulation in AMD mouse models.Adv Exp Med Biol, vol. 801, 2014, pp. 213–19. Pubmed, doi:10.1007/978-1-4614-3209-8_28.
Ding J-D, Kelly U, Groelle M, Christenbury JG, Zhang W, Bowes Rickman C. The role of complement dysregulation in AMD mouse models. Adv Exp Med Biol. 2014;801:213–219.

Published In

Adv Exp Med Biol

DOI

ISSN

0065-2598

Publication Date

2014

Volume

801

Start / End Page

213 / 219

Location

United States

Related Subject Headings

  • Mice, Knockout
  • Mice
  • Macular Degeneration
  • Kidney Diseases
  • Humans
  • Hereditary Complement Deficiency Diseases
  • General & Internal Medicine
  • Disease Models, Animal
  • Complement System Proteins
  • Complement Factor H