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Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei.

Publication ,  Journal Article
Tauchi, M; Zhang, R; D'Alessio, DA; Stern, JE; Herman, JP
Published in: J Chem Neuroanat
December 2008

Glucagon-like peptide-1 (GLP-1) plays a role in modulating neuroendocrine and autonomic function. The hypothalamic paraventricular nucleus (PVN) contains aggregations of GLP-1 fibers and expresses GLP-1 receptors, making it a likely site of action for GLP-1 signaling. The current study was designed to establish domains of GLP-1 action, focusing on axosomatic appositions on different neuroendocrine and autonomic cell populations in the PVN. The data indicate abundant GLP-1-immunoreactive terminal appositions on corticotropin-releasing hormone neurons in the medial parvocellular PVN. GLP-1 positive boutons can also be observed in apposition to oxytocinergic neurons and on retrogradely labeled pre-autonomic neurons projecting to the region of the nucleus of the solitary tract. In contrast, there were very few vasopressinergic neurons with GLP-1 appositions. Overall, the data indicate that the central GLP-1 system preferentially targets neurons in hypophysiotrophic zones of the PVN, consistent with excitatory actions of GLP-1 on adrenocorticotropin release. GLP-1 is also in position to influence oxytocin secretion and control outflow to brainstem cardiovascular relays.

Duke Scholars

Published In

J Chem Neuroanat

DOI

ISSN

0891-0618

Publication Date

December 2008

Volume

36

Issue

3-4

Start / End Page

144 / 149

Location

Netherlands

Related Subject Headings

  • Supraoptic Nucleus
  • Rats, Sprague-Dawley
  • Rats, Long-Evans
  • Rats
  • Presynaptic Terminals
  • Paraventricular Hypothalamic Nucleus
  • Oxytocin
  • Neurophysins
  • Neurology & Neurosurgery
  • Nerve Fibers
 

Citation

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ICMJE
MLA
NLM
Tauchi, M., Zhang, R., D’Alessio, D. A., Stern, J. E., & Herman, J. P. (2008). Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei. J Chem Neuroanat, 36(3–4), 144–149. https://doi.org/10.1016/j.jchemneu.2008.07.009
Tauchi, Miyuki, Rong Zhang, David A. D’Alessio, Javier E. Stern, and James P. Herman. “Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei.J Chem Neuroanat 36, no. 3–4 (December 2008): 144–49. https://doi.org/10.1016/j.jchemneu.2008.07.009.
Tauchi M, Zhang R, D’Alessio DA, Stern JE, Herman JP. Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei. J Chem Neuroanat. 2008 Dec;36(3–4):144–9.
Tauchi, Miyuki, et al. “Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei.J Chem Neuroanat, vol. 36, no. 3–4, Dec. 2008, pp. 144–49. Pubmed, doi:10.1016/j.jchemneu.2008.07.009.
Tauchi M, Zhang R, D’Alessio DA, Stern JE, Herman JP. Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei. J Chem Neuroanat. 2008 Dec;36(3–4):144–149.
Journal cover image

Published In

J Chem Neuroanat

DOI

ISSN

0891-0618

Publication Date

December 2008

Volume

36

Issue

3-4

Start / End Page

144 / 149

Location

Netherlands

Related Subject Headings

  • Supraoptic Nucleus
  • Rats, Sprague-Dawley
  • Rats, Long-Evans
  • Rats
  • Presynaptic Terminals
  • Paraventricular Hypothalamic Nucleus
  • Oxytocin
  • Neurophysins
  • Neurology & Neurosurgery
  • Nerve Fibers