New ways in which GLP-1 can regulate glucose homeostasis.
Publication
, Journal Article
D'Alessio, DA; Sandoval, DA; Seeley, RJ
Published in: J Clin Invest
December 2005
Glucagon-like peptide-1 (GLP-1) has a diverse set of peripheral actions which all serve to promote enhanced glucose tolerance, and for this reason it has become the basis for new treatments for type 2 diabetes. In this issue of the JCI, Knauf et al. provide clear evidence that GLP-1 signaling in the CNS is also linked to the control of peripheral glucose homeostasis by inhibiting non-insulin-mediated glucose uptake by muscle and increasing insulin secretion from the pancreas. The authors' work points to an important need to integrate diverse GLP-1 signaling actions and peripheral GLP-1 function in order to better understand both normal and abnormal glucose homeostasis.
Duke Scholars
Published In
J Clin Invest
DOI
ISSN
0021-9738
Publication Date
December 2005
Volume
115
Issue
12
Start / End Page
3406 / 3408
Location
United States
Related Subject Headings
- Proglucagon
- Peptide Fragments
- Models, Biological
- Insulin
- Immunology
- Humans
- Homeostasis
- Glucose
- Glucagon-Like Peptide 1
- Glucagon
Citation
APA
Chicago
ICMJE
MLA
NLM
D’Alessio, D. A., Sandoval, D. A., & Seeley, R. J. (2005). New ways in which GLP-1 can regulate glucose homeostasis. J Clin Invest, 115(12), 3406–3408. https://doi.org/10.1172/JCI27207
D’Alessio, David A., Darleen A. Sandoval, and Randy J. Seeley. “New ways in which GLP-1 can regulate glucose homeostasis.” J Clin Invest 115, no. 12 (December 2005): 3406–8. https://doi.org/10.1172/JCI27207.
D’Alessio DA, Sandoval DA, Seeley RJ. New ways in which GLP-1 can regulate glucose homeostasis. J Clin Invest. 2005 Dec;115(12):3406–8.
D’Alessio, David A., et al. “New ways in which GLP-1 can regulate glucose homeostasis.” J Clin Invest, vol. 115, no. 12, Dec. 2005, pp. 3406–08. Pubmed, doi:10.1172/JCI27207.
D’Alessio DA, Sandoval DA, Seeley RJ. New ways in which GLP-1 can regulate glucose homeostasis. J Clin Invest. 2005 Dec;115(12):3406–3408.
Published In
J Clin Invest
DOI
ISSN
0021-9738
Publication Date
December 2005
Volume
115
Issue
12
Start / End Page
3406 / 3408
Location
United States
Related Subject Headings
- Proglucagon
- Peptide Fragments
- Models, Biological
- Insulin
- Immunology
- Humans
- Homeostasis
- Glucose
- Glucagon-Like Peptide 1
- Glucagon