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Cloned mice have an obese phenotype not transmitted to their offspring.

Publication ,  Journal Article
Tamashiro, KLK; Wakayama, T; Akutsu, H; Yamazaki, Y; Lachey, JL; Wortman, MD; Seeley, RJ; D'Alessio, DA; Woods, SC; Yanagimachi, R; Sakai, RR
Published in: Nat Med
March 2002

Mammalian cloning using somatic cells has been accomplished successfully in several species, and its potential basic, clinical and therapeutic applications are being pursued on many fronts. Determining the long-term effects of cloning on offspring is crucial for consideration of future application of the technique. Although full-term development of animals cloned from adult somatic cells has been reported, problems in the resulting progeny indicate that the cloning procedure may not produce animals that are phenotypically identical to their cell donor. We used a mouse model to take advantage of its short generation time and lifespan. Here we report that the increased body weight of cloned B6C3F1 female mice reflects an increase of body fat in addition to a larger body size, and that these mice share many characteristics consistent with obesity. We also show that the obese phenotype is not transmitted to offspring generated by mating male and female cloned mice.

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Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

March 2002

Volume

8

Issue

3

Start / End Page

262 / 267

Location

United States

Related Subject Headings

  • alpha-MSH
  • Pregnancy
  • Phenotype
  • Obesity
  • Mice
  • Male
  • Leptin
  • Insulin
  • Immunology
  • Food Deprivation
 

Citation

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Tamashiro, K. L. K., Wakayama, T., Akutsu, H., Yamazaki, Y., Lachey, J. L., Wortman, M. D., … Sakai, R. R. (2002). Cloned mice have an obese phenotype not transmitted to their offspring. Nat Med, 8(3), 262–267. https://doi.org/10.1038/nm0302-262
Tamashiro, Kellie L. K., Teruhiko Wakayama, Hidenori Akutsu, Yukiko Yamazaki, Jennifer L. Lachey, Matthew D. Wortman, Randy J. Seeley, et al. “Cloned mice have an obese phenotype not transmitted to their offspring.Nat Med 8, no. 3 (March 2002): 262–67. https://doi.org/10.1038/nm0302-262.
Tamashiro KLK, Wakayama T, Akutsu H, Yamazaki Y, Lachey JL, Wortman MD, et al. Cloned mice have an obese phenotype not transmitted to their offspring. Nat Med. 2002 Mar;8(3):262–7.
Tamashiro, Kellie L. K., et al. “Cloned mice have an obese phenotype not transmitted to their offspring.Nat Med, vol. 8, no. 3, Mar. 2002, pp. 262–67. Pubmed, doi:10.1038/nm0302-262.
Tamashiro KLK, Wakayama T, Akutsu H, Yamazaki Y, Lachey JL, Wortman MD, Seeley RJ, D’Alessio DA, Woods SC, Yanagimachi R, Sakai RR. Cloned mice have an obese phenotype not transmitted to their offspring. Nat Med. 2002 Mar;8(3):262–267.

Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

March 2002

Volume

8

Issue

3

Start / End Page

262 / 267

Location

United States

Related Subject Headings

  • alpha-MSH
  • Pregnancy
  • Phenotype
  • Obesity
  • Mice
  • Male
  • Leptin
  • Insulin
  • Immunology
  • Food Deprivation