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GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats.

Publication ,  Journal Article
Qin, X; Shen, H; Liu, M; Yang, Q; Zheng, S; Sabo, M; D'Alessio, DA; Tso, P
Published in: Am J Physiol Gastrointest Liver Physiol
May 2005

Glucagon-like peptide 1 (GLP-1) is a gastrointestinal hormone secreted in response to meal ingestion by enteroendocrine L cells located predominantly in the lower small intestine and large intestine. GLP-1 inhibits the secretion and motility of the upper gut and has been suggested to play a role in the "ileal brake." In this study, we investigated the effect of recombinant GLP-1-(7-36) amide (rGLP-1) on lipid absorption in the small intestine in intestinal lymph duct-cannulated rats. In addition, the effects of rGLP-1 on intestinal production of apolipoprotein (apo) B and apo A-IV, two apolipoproteins closely related to lipid absorption, were evaluated. rGLP-1 was infused through the jugular vein, and lipids were infused simultaneously through a duodenal cannula. Our results showed that infusion of rGLP-1 at 20 pmol.kg(-1).min(-1) caused a dramatic and prompt decrease in lymph flow from 2.22 +/- 0.15 (SE) ml/h at baseline (n = 6) to 1.24 +/- 0.06 ml/h at 2 h (P < 0.001). In contrast, a significant increase in lymph flow was observed in the saline (control) group: 2.19 +/- 0.20 and 3.48 +/- 0.09 ml/h at baseline and at 6 h of lipid infusion, respectively (P < 0.001). rGLP-1 also inhibited intestinal triolein absorption (P < 0.05) and lymphatic apo B and apo A-IV output (P < 0.05) but did not affect cholesterol absorption. In conclusion, rGLP-1 dramatically decreases intestinal lymph flow and reduces triglyceride absorption and apo B and apo A-IV production. These findings suggest a novel role for GLP-1 in lipid absorption.

Duke Scholars

Published In

Am J Physiol Gastrointest Liver Physiol

DOI

ISSN

0193-1857

Publication Date

May 2005

Volume

288

Issue

5

Start / End Page

G943 / G949

Location

United States

Related Subject Headings

  • Triglycerides
  • Time Factors
  • Recombinant Proteins
  • Rats, Sprague-Dawley
  • Rats
  • Peptide Fragments
  • Male
  • Lymph
  • Intestine, Small
  • Intestinal Mucosa
 

Citation

APA
Chicago
ICMJE
MLA
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Qin, X., Shen, H., Liu, M., Yang, Q., Zheng, S., Sabo, M., … Tso, P. (2005). GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats. Am J Physiol Gastrointest Liver Physiol, 288(5), G943–G949. https://doi.org/10.1152/ajpgi.00303.2004
Qin, Xiaofa, Hui Shen, Min Liu, Qing Yang, Shuqin Zheng, Mary Sabo, David A. D’Alessio, and Patrick Tso. “GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats.Am J Physiol Gastrointest Liver Physiol 288, no. 5 (May 2005): G943–49. https://doi.org/10.1152/ajpgi.00303.2004.
Qin X, Shen H, Liu M, Yang Q, Zheng S, Sabo M, et al. GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats. Am J Physiol Gastrointest Liver Physiol. 2005 May;288(5):G943–9.
Qin, Xiaofa, et al. “GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats.Am J Physiol Gastrointest Liver Physiol, vol. 288, no. 5, May 2005, pp. G943–49. Pubmed, doi:10.1152/ajpgi.00303.2004.
Qin X, Shen H, Liu M, Yang Q, Zheng S, Sabo M, D’Alessio DA, Tso P. GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats. Am J Physiol Gastrointest Liver Physiol. 2005 May;288(5):G943–G949.

Published In

Am J Physiol Gastrointest Liver Physiol

DOI

ISSN

0193-1857

Publication Date

May 2005

Volume

288

Issue

5

Start / End Page

G943 / G949

Location

United States

Related Subject Headings

  • Triglycerides
  • Time Factors
  • Recombinant Proteins
  • Rats, Sprague-Dawley
  • Rats
  • Peptide Fragments
  • Male
  • Lymph
  • Intestine, Small
  • Intestinal Mucosa