Skip to main content
Journal cover image

Adjusting for misclassification in a stratified biomarker clinical trial.

Publication ,  Journal Article
Liu, C; Liu, A; Hu, J; Yuan, V; Halabi, S
Published in: Stat Med
August 15, 2014

Clinical trials utilizing predictive biomarkers have become a research focus in personalized medicine. We investigate the effects of biomarker misclassification on the design and analysis of stratified biomarker clinical trials. For a variety of inference problems including marker-treatment interaction in particular, we show that marker misclassification may have profound adverse effects on the coverage of confidence intervals, power of the tests, and required sample sizes. For each inferential problem, we propose methods to adjust for the classification errors.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Stat Med

DOI

EISSN

1097-0258

Publication Date

August 15, 2014

Volume

33

Issue

18

Start / End Page

3100 / 3113

Location

England

Related Subject Headings

  • Statistics & Probability
  • Sample Size
  • Precision Medicine
  • Neoplasms
  • Models, Statistical
  • Kidney Neoplasms
  • Interleukin-6
  • Humans
  • Confidence Intervals
  • Clinical Trials, Phase III as Topic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liu, C., Liu, A., Hu, J., Yuan, V., & Halabi, S. (2014). Adjusting for misclassification in a stratified biomarker clinical trial. Stat Med, 33(18), 3100–3113. https://doi.org/10.1002/sim.6164
Liu, Chunling, Aiyi Liu, Jiang Hu, Vivian Yuan, and Susan Halabi. “Adjusting for misclassification in a stratified biomarker clinical trial.Stat Med 33, no. 18 (August 15, 2014): 3100–3113. https://doi.org/10.1002/sim.6164.
Liu C, Liu A, Hu J, Yuan V, Halabi S. Adjusting for misclassification in a stratified biomarker clinical trial. Stat Med. 2014 Aug 15;33(18):3100–13.
Liu, Chunling, et al. “Adjusting for misclassification in a stratified biomarker clinical trial.Stat Med, vol. 33, no. 18, Aug. 2014, pp. 3100–13. Pubmed, doi:10.1002/sim.6164.
Liu C, Liu A, Hu J, Yuan V, Halabi S. Adjusting for misclassification in a stratified biomarker clinical trial. Stat Med. 2014 Aug 15;33(18):3100–3113.
Journal cover image

Published In

Stat Med

DOI

EISSN

1097-0258

Publication Date

August 15, 2014

Volume

33

Issue

18

Start / End Page

3100 / 3113

Location

England

Related Subject Headings

  • Statistics & Probability
  • Sample Size
  • Precision Medicine
  • Neoplasms
  • Models, Statistical
  • Kidney Neoplasms
  • Interleukin-6
  • Humans
  • Confidence Intervals
  • Clinical Trials, Phase III as Topic