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Biomarkers for osteoarthritis: current position and steps towards further validation.

Publication ,  Journal Article
Hunter, DJ; Nevitt, M; Losina, E; Kraus, V
Published in: Best Pract Res Clin Rheumatol
February 2014

Historically disease knowledge development and treatment innovation in osteoarthritis (OA) has been considered to be slow. One of the many reasons purported as responsible for this slow pace has been the alleged lack of valid and responsive biomarkers to ascertain efficacy, which itself has been dependent upon the slow evolution of the understanding of the complex nature of joint tissue biology. This narrative review outlines the rationale for why we need OA biomarkers with regard to biomarker validation and qualification. The main biomarkers in current development for OA are biochemical and imaging markers. We describe an approach to biomarker validation and qualification for OA clinical trials that has recently commenced with the Foundation of NIH OA Biomarkers Consortium study cosponsored by the Osteoarthritis Research Society International (OARSI). With this approach we endeavor to identify, develop, and qualify biological markers (biomarkers) to support new drug development, preventive medicine, and medical diagnostics for osteoarthritis.

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Published In

Best Pract Res Clin Rheumatol

DOI

EISSN

1532-1770

Publication Date

February 2014

Volume

28

Issue

1

Start / End Page

61 / 71

Location

Netherlands

Related Subject Headings

  • Validation Studies as Topic
  • Osteoarthritis
  • Humans
  • Biomarkers
  • Arthritis & Rheumatology
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences
 

Citation

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Hunter, D. J., Nevitt, M., Losina, E., & Kraus, V. (2014). Biomarkers for osteoarthritis: current position and steps towards further validation. Best Pract Res Clin Rheumatol, 28(1), 61–71. https://doi.org/10.1016/j.berh.2014.01.007
Hunter, David J., Michael Nevitt, Elena Losina, and Virginia Kraus. “Biomarkers for osteoarthritis: current position and steps towards further validation.Best Pract Res Clin Rheumatol 28, no. 1 (February 2014): 61–71. https://doi.org/10.1016/j.berh.2014.01.007.
Hunter DJ, Nevitt M, Losina E, Kraus V. Biomarkers for osteoarthritis: current position and steps towards further validation. Best Pract Res Clin Rheumatol. 2014 Feb;28(1):61–71.
Hunter, David J., et al. “Biomarkers for osteoarthritis: current position and steps towards further validation.Best Pract Res Clin Rheumatol, vol. 28, no. 1, Feb. 2014, pp. 61–71. Pubmed, doi:10.1016/j.berh.2014.01.007.
Hunter DJ, Nevitt M, Losina E, Kraus V. Biomarkers for osteoarthritis: current position and steps towards further validation. Best Pract Res Clin Rheumatol. 2014 Feb;28(1):61–71.
Journal cover image

Published In

Best Pract Res Clin Rheumatol

DOI

EISSN

1532-1770

Publication Date

February 2014

Volume

28

Issue

1

Start / End Page

61 / 71

Location

Netherlands

Related Subject Headings

  • Validation Studies as Topic
  • Osteoarthritis
  • Humans
  • Biomarkers
  • Arthritis & Rheumatology
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
  • 1103 Clinical Sciences