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Statin therapy and thromboxane generation in patients with coronary artery disease treated with high-dose aspirin.

Publication ,  Journal Article
Bliden, KP; Singla, A; Gesheff, MG; Toth, PP; Tabrizchi, A; Ens, G; Guyer, K; Singh, M; Franzese, CJ; Stapleton, D; Tantry, US; Gurbel, PA
Published in: Thromb Haemost
August 2014

Aspirin and statin therapy are mainstay treatments in patients with coronary artery disease (CAD). The relation between statin therapy, in vivo thromboxane (Tx) generation; a marker of inflammation, and blood thrombogenicity has never been explored. Urinary 11-dehydro (dh) TxB2 was determined in patients with suspected CAD on 325 mg daily aspirin therapy prior to undergoing cardiac catheterisation (n=281). Thrombogenicity was estimated by thrombelastographic measurement of thrombin-induced platelet-fibrin clot strength (TIP-FCS) and lipids/lipoproteins were determined by vertical density gradient ultracentrifugation/ELISA. The influence of statin therapy and dose was analysed by the atorvastatin equivalent dose (5-10 mg, 20-40 mg, or 80 mg daily). Statin therapy (n=186) was associated with a dose-dependent reduction in urinary 11-dh TxB2 (p=0.046) that was independent of LDL and apo B100 levels but was strongly related to TIP-FCS (p=0.006). By multivariate analysis, no statin therapy (n=95) and female gender were independently associated with high urinary 11-dh TxB2 [OR=2.95 (0.1.57-5.50, p=0.0007); OR=2.25 (1.24-4.05, p=0.007)], respectively. In aspirin-treated patients, statin therapy was independently and inversely associated with inflammation in a dose-dependent manner. Elevated 11-dh TxB2 was associated with a prothrombotic state indicated by high TIP-FCS. Our data suggest that measurement of urinary 11-dTxB2 may be a useful method to optimise statin dosing in order to reduce thrombotic risk.

Duke Scholars

Published In

Thromb Haemost

DOI

EISSN

2567-689X

Publication Date

August 2014

Volume

112

Issue

2

Start / End Page

323 / 331

Location

Germany

Related Subject Headings

  • Ultracentrifugation
  • Treatment Outcome
  • Thromboxane B2
  • Thrombelastography
  • Sex Factors
  • Risk Factors
  • Proportional Hazards Models
  • Platelet Aggregation Inhibitors
  • Odds Ratio
  • Multivariate Analysis
 

Citation

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Bliden, K. P., Singla, A., Gesheff, M. G., Toth, P. P., Tabrizchi, A., Ens, G., … Gurbel, P. A. (2014). Statin therapy and thromboxane generation in patients with coronary artery disease treated with high-dose aspirin. Thromb Haemost, 112(2), 323–331. https://doi.org/10.1160/TH14-01-0094
Bliden, K. P., A. Singla, M. G. Gesheff, P. P. Toth, A. Tabrizchi, G. Ens, K. Guyer, et al. “Statin therapy and thromboxane generation in patients with coronary artery disease treated with high-dose aspirin.Thromb Haemost 112, no. 2 (August 2014): 323–31. https://doi.org/10.1160/TH14-01-0094.
Bliden KP, Singla A, Gesheff MG, Toth PP, Tabrizchi A, Ens G, et al. Statin therapy and thromboxane generation in patients with coronary artery disease treated with high-dose aspirin. Thromb Haemost. 2014 Aug;112(2):323–31.
Bliden, K. P., et al. “Statin therapy and thromboxane generation in patients with coronary artery disease treated with high-dose aspirin.Thromb Haemost, vol. 112, no. 2, Aug. 2014, pp. 323–31. Pubmed, doi:10.1160/TH14-01-0094.
Bliden KP, Singla A, Gesheff MG, Toth PP, Tabrizchi A, Ens G, Guyer K, Singh M, Franzese CJ, Stapleton D, Tantry US, Gurbel PA. Statin therapy and thromboxane generation in patients with coronary artery disease treated with high-dose aspirin. Thromb Haemost. 2014 Aug;112(2):323–331.
Journal cover image

Published In

Thromb Haemost

DOI

EISSN

2567-689X

Publication Date

August 2014

Volume

112

Issue

2

Start / End Page

323 / 331

Location

Germany

Related Subject Headings

  • Ultracentrifugation
  • Treatment Outcome
  • Thromboxane B2
  • Thrombelastography
  • Sex Factors
  • Risk Factors
  • Proportional Hazards Models
  • Platelet Aggregation Inhibitors
  • Odds Ratio
  • Multivariate Analysis