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Associations between central nervous system serotonin, fasting glucose, and hostility in African American females.

Publication ,  Journal Article
Boyle, SH; Georgiades, A; Brummett, BH; Barefoot, JC; Siegler, IC; Matson, WR; Kuhn, CM; Grichnik, K; Stafford-Smith, M; Williams, RB ...
Published in: Ann Behav Med
February 2015

BACKGROUND: Previous research has shown an association between hostility and fasting glucose in African American women. Central nervous system serotonin activity is implicated both in metabolic processes and in hostility related traits. PURPOSE: The purpose of this study is to determine whether central nervous system serotonin influences the association between hostility and fasting glucose in African American women. METHODS: The study consisted of 119 healthy volunteers (36 African American women, 27 White women, 21 White males, and 35 African American males, mean age 34 ± 8.5 years). Serotonin related compounds were measured in cerebrospinal fluid. Hostility was measured by the Cook-Medley Hostility Scale. RESULTS: Hostility was associated with fasting glucose and central nervous system serotonin related compounds in African American women only. Controlling for the serotonin related compounds significantly reduced the association of hostility to glucose. CONCLUSIONS: The positive correlation between hostility and fasting glucose in African American women can partly be explained by central nervous system serotonin function.

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Published In

Ann Behav Med

DOI

EISSN

1532-4796

Publication Date

February 2015

Volume

49

Issue

1

Start / End Page

49 / 57

Location

England

Related Subject Headings

  • Young Adult
  • White People
  • Serotonin
  • Public Health
  • Middle Aged
  • Male
  • Humans
  • Hostility
  • Female
  • Fasting
 

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Boyle, S. H., Georgiades, A., Brummett, B. H., Barefoot, J. C., Siegler, I. C., Matson, W. R., … Surwit, R. S. (2015). Associations between central nervous system serotonin, fasting glucose, and hostility in African American females. Ann Behav Med, 49(1), 49–57. https://doi.org/10.1007/s12160-014-9626-7
Boyle, Stephen H., Anastasia Georgiades, Beverly H. Brummett, John C. Barefoot, Ilene C. Siegler, Wayne R. Matson, Cynthia M. Kuhn, et al. “Associations between central nervous system serotonin, fasting glucose, and hostility in African American females.Ann Behav Med 49, no. 1 (February 2015): 49–57. https://doi.org/10.1007/s12160-014-9626-7.
Boyle SH, Georgiades A, Brummett BH, Barefoot JC, Siegler IC, Matson WR, et al. Associations between central nervous system serotonin, fasting glucose, and hostility in African American females. Ann Behav Med. 2015 Feb;49(1):49–57.
Boyle, Stephen H., et al. “Associations between central nervous system serotonin, fasting glucose, and hostility in African American females.Ann Behav Med, vol. 49, no. 1, Feb. 2015, pp. 49–57. Pubmed, doi:10.1007/s12160-014-9626-7.
Boyle SH, Georgiades A, Brummett BH, Barefoot JC, Siegler IC, Matson WR, Kuhn CM, Grichnik K, Stafford-Smith M, Williams RB, Kaddurah-Daouk R, Surwit RS. Associations between central nervous system serotonin, fasting glucose, and hostility in African American females. Ann Behav Med. 2015 Feb;49(1):49–57.
Journal cover image

Published In

Ann Behav Med

DOI

EISSN

1532-4796

Publication Date

February 2015

Volume

49

Issue

1

Start / End Page

49 / 57

Location

England

Related Subject Headings

  • Young Adult
  • White People
  • Serotonin
  • Public Health
  • Middle Aged
  • Male
  • Humans
  • Hostility
  • Female
  • Fasting