Skip to main content

Magnetophoretic circuits for digital control of single particles and cells

Publication ,  Journal Article
Lim, B; Reddy, V; Hu, X; Kim, K; Jadhav, M; Abedini-Nassab, R; Noh, Y; Lim, YT; Yellen, BB; Kim, C
Published in: Nature Communications
May 14, 2014

The ability to manipulate small fluid droplets, colloidal particles and single cells with the precision and parallelization of modern-day computer hardware has profound applications for biochemical detection, gene sequencing, chemical synthesis and highly parallel analysis of single cells. Drawing inspiration from general circuit theory and magnetic bubble technology, here we demonstrate a class of integrated circuits for executing sequential and parallel, timed operations on an ensemble of single particles and cells. The integrated circuits are constructed from lithographically defined, overlaid patterns of magnetic film and current lines. The magnetic patterns passively control particles similar to electrical conductors, diodes and capacitors. The current lines actively switch particles between different tracks similar to gated electrical transistors. When combined into arrays and driven by a rotating magnetic field clock, these integrated circuits have general multiplexing properties and enable the precise control of magnetizable objects.

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nature Communications

DOI

Publication Date

May 14, 2014

Volume

5

Publisher

Nature Publishing Group

Related Subject Headings

  • Single-Cell Analysis
  • Nanoparticles
  • Magnets
  • Hydrodynamics
  • Computers
  • Colloids
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lim, B., Reddy, V., Hu, X., Kim, K., Jadhav, M., Abedini-Nassab, R., … Kim, C. (2014). Magnetophoretic circuits for digital control of single particles and cells. Nature Communications, 5. https://doi.org/10.1038/ncomms4846
Lim, B., V. Reddy, X. Hu, K. Kim, M. Jadhav, R. Abedini-Nassab, Y. Noh, Y. T. Lim, B. B. Yellen, and C. Kim. “Magnetophoretic circuits for digital control of single particles and cells.” Nature Communications 5 (May 14, 2014). https://doi.org/10.1038/ncomms4846.
Lim B, Reddy V, Hu X, Kim K, Jadhav M, Abedini-Nassab R, et al. Magnetophoretic circuits for digital control of single particles and cells. Nature Communications. 2014 May 14;5.
Lim, B., et al. “Magnetophoretic circuits for digital control of single particles and cells.” Nature Communications, vol. 5, Nature Publishing Group, May 2014. Manual, doi:10.1038/ncomms4846.
Lim B, Reddy V, Hu X, Kim K, Jadhav M, Abedini-Nassab R, Noh Y, Lim YT, Yellen BB, Kim C. Magnetophoretic circuits for digital control of single particles and cells. Nature Communications. Nature Publishing Group; 2014 May 14;5.

Published In

Nature Communications

DOI

Publication Date

May 14, 2014

Volume

5

Publisher

Nature Publishing Group

Related Subject Headings

  • Single-Cell Analysis
  • Nanoparticles
  • Magnets
  • Hydrodynamics
  • Computers
  • Colloids