Cross-reactive potential of human T-lymphocyte responses in HIV-1 infection.
Publication
, Journal Article
Giorgi, EE; Balachandran, H; Muldoon, M; Letvin, NL; Haynes, BF; Korber, BT; Santra, S
Published in: Vaccine
June 30, 2014
An effective HIV-1 vaccine should elicit sufficient breadth of immune recognition to protect against the genetically diverse forms of the circulating virus. Evaluation of the breadth and magnitude of cellular immune responses to epitope variants is important for HIV-1 vaccine assessment. We compared HIV-1 Gag-specific T-lymphocyte responses in 20 HIV-1-infected individuals representing two different HIV-1 subtypes, B and C. By assessing T lymphocyte responses with peptides based on natural HIV-1 variants, we found evidence for limited cross-reactivity and significantly enhanced within-clade responses among clade B-infected subjects, and not among clade C-infected subjects.
Duke Scholars
Published In
Vaccine
DOI
EISSN
1873-2518
Publication Date
June 30, 2014
Volume
32
Issue
31
Start / End Page
3995 / 4000
Location
Netherlands
Related Subject Headings
- gag Gene Products, Human Immunodeficiency Virus
- Virology
- T-Lymphocytes
- Humans
- HIV-1
- HIV Infections
- Epitopes, T-Lymphocyte
- Cross Reactions
- 42 Health sciences
- 32 Biomedical and clinical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Giorgi, E. E., Balachandran, H., Muldoon, M., Letvin, N. L., Haynes, B. F., Korber, B. T., & Santra, S. (2014). Cross-reactive potential of human T-lymphocyte responses in HIV-1 infection. Vaccine, 32(31), 3995–4000. https://doi.org/10.1016/j.vaccine.2014.04.040
Giorgi, Elena E., Harikrishnan Balachandran, Mark Muldoon, Norman L. Letvin, Barton F. Haynes, Bette T. Korber, and Sampa Santra. “Cross-reactive potential of human T-lymphocyte responses in HIV-1 infection.” Vaccine 32, no. 31 (June 30, 2014): 3995–4000. https://doi.org/10.1016/j.vaccine.2014.04.040.
Giorgi EE, Balachandran H, Muldoon M, Letvin NL, Haynes BF, Korber BT, et al. Cross-reactive potential of human T-lymphocyte responses in HIV-1 infection. Vaccine. 2014 Jun 30;32(31):3995–4000.
Giorgi, Elena E., et al. “Cross-reactive potential of human T-lymphocyte responses in HIV-1 infection.” Vaccine, vol. 32, no. 31, June 2014, pp. 3995–4000. Pubmed, doi:10.1016/j.vaccine.2014.04.040.
Giorgi EE, Balachandran H, Muldoon M, Letvin NL, Haynes BF, Korber BT, Santra S. Cross-reactive potential of human T-lymphocyte responses in HIV-1 infection. Vaccine. 2014 Jun 30;32(31):3995–4000.
Published In
Vaccine
DOI
EISSN
1873-2518
Publication Date
June 30, 2014
Volume
32
Issue
31
Start / End Page
3995 / 4000
Location
Netherlands
Related Subject Headings
- gag Gene Products, Human Immunodeficiency Virus
- Virology
- T-Lymphocytes
- Humans
- HIV-1
- HIV Infections
- Epitopes, T-Lymphocyte
- Cross Reactions
- 42 Health sciences
- 32 Biomedical and clinical sciences