Skip to main content
Journal cover image

Comparing 3-T multiparametric MRI and the Partin tables to predict organ-confined prostate cancer after radical prostatectomy.

Publication ,  Journal Article
Gupta, RT; Faridi, KF; Singh, AA; Passoni, NM; Garcia-Reyes, K; Madden, JF; Polascik, TJ
Published in: Urol Oncol
November 2014

OBJECTIVES: The purpose of our study was to test our hypothesis that multiparametric magnetic resonance imaging (mpMRI) may have a higher prognostic accuracy than the Partin tables in predicting organ-confined (OC) prostate cancer and extracapsular extension (ECE) after radical prostatectomy (RP). METHODS AND MATERIALS: After institutional review board approval, we retrospectively reviewed 60 patients who underwent 3-T mpMRI before RP. mpMRI was used to assess clinical stage and the updated version of the Partin tables was used to calculate the probability of each patient to harbor OC disease. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of mpMRI in detecting OC and ECE were calculated. Logistic regression models predicting OC pathology were created using either clinical stage at mpMRI or Partin tables probability. The area under the curve was used to calculate the predictive accuracy of each model. RESULTS: Median prostate-specific antigen level at diagnosis was 5 ng/ml (range: 4.1-6.7 ng/ml). Overall, 52 (86.7%) men had cT1 disease, 7 (11.7%) had cT2a/b, and 1 (1.6%) had cT3b at digital rectal examination. Biopsy Gleason score was 6, 3+4 = 7, 4+3 = 7, 8, and 9 to 10 in 28 (46.7%), 15 (25%), 3 (5%), 10 (16.7%), and 4 (6.6%) patients, respectively. At mpMRI, clinical stage was defined as cT2a/b, cT2c, cT3a, and cT3b in 11 (18.3%), 23 (38.3%), 21 (35%), and 5 (8.4%) patients, respectively. At final pathology, 38 men (63.3%) had OC disease, whereas 18 (30%) had ECE and 4 (6.7%) had seminal vesicle invasion. The sensitivity, specificity, PPV, and NPV of mpMRI in detecting OC disease were 81.6%, 86.4%, 91.2%, and 73.1%, respectively, whereas in detecting ECE were 77.8%, 83.4%, 66.7%, and 89.7%, respectively. At logistic regression, both the Partin tables-derived probability and the mpMRI clinical staging were significantly associated with OC disease (all P<0.01). The area under the curves of the model built using the Partin tables and that of the mpMRI model were 0.62 and 0.82, respectively (P = 0.04). CONCLUSIONS: The predictive accuracy of mpMRI in predicting OC disease on pathological analysis is significantly greater than that of the Partin tables. mpMRI had a high PPV (91.2%) when predicting OC disease and a high NPV (89.7%) with regard to ECE. mpMRI should be considered when planning prostate cancer treatment in addition to readily available clinical parameters.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Urol Oncol

DOI

EISSN

1873-2496

Publication Date

November 2014

Volume

32

Issue

8

Start / End Page

1292 / 1299

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Prostatic Neoplasms
  • Prostatectomy
  • Prognosis
  • Neoplasm Staging
  • Models, Statistical
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gupta, R. T., Faridi, K. F., Singh, A. A., Passoni, N. M., Garcia-Reyes, K., Madden, J. F., & Polascik, T. J. (2014). Comparing 3-T multiparametric MRI and the Partin tables to predict organ-confined prostate cancer after radical prostatectomy. Urol Oncol, 32(8), 1292–1299. https://doi.org/10.1016/j.urolonc.2014.04.017
Gupta, Rajan T., Kamil F. Faridi, Abhay A. Singh, Niccolò M. Passoni, Kirema Garcia-Reyes, John F. Madden, and Thomas J. Polascik. “Comparing 3-T multiparametric MRI and the Partin tables to predict organ-confined prostate cancer after radical prostatectomy.Urol Oncol 32, no. 8 (November 2014): 1292–99. https://doi.org/10.1016/j.urolonc.2014.04.017.
Gupta RT, Faridi KF, Singh AA, Passoni NM, Garcia-Reyes K, Madden JF, et al. Comparing 3-T multiparametric MRI and the Partin tables to predict organ-confined prostate cancer after radical prostatectomy. Urol Oncol. 2014 Nov;32(8):1292–9.
Gupta, Rajan T., et al. “Comparing 3-T multiparametric MRI and the Partin tables to predict organ-confined prostate cancer after radical prostatectomy.Urol Oncol, vol. 32, no. 8, Nov. 2014, pp. 1292–99. Pubmed, doi:10.1016/j.urolonc.2014.04.017.
Gupta RT, Faridi KF, Singh AA, Passoni NM, Garcia-Reyes K, Madden JF, Polascik TJ. Comparing 3-T multiparametric MRI and the Partin tables to predict organ-confined prostate cancer after radical prostatectomy. Urol Oncol. 2014 Nov;32(8):1292–1299.
Journal cover image

Published In

Urol Oncol

DOI

EISSN

1873-2496

Publication Date

November 2014

Volume

32

Issue

8

Start / End Page

1292 / 1299

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Prostatic Neoplasms
  • Prostatectomy
  • Prognosis
  • Neoplasm Staging
  • Models, Statistical
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans