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Phenotype standardization for statin-induced myotoxicity.

Publication ,  Journal Article
Alfirevic, A; Neely, D; Armitage, J; Chinoy, H; Cooper, RG; Laaksonen, R; Carr, DF; Bloch, KM; Fahy, J; Hanson, A; Yue, Q-Y; Wadelius, M ...
Published in: Clin Pharmacol Ther
October 2014

Statins are widely used lipid-lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can cause muscle toxicity, which can lead to severe rhabdomyolysis. Research in this area has been hampered to some extent by the lack of standardized nomenclature and phenotypic definitions. We have used numerical and descriptive classifications and developed an algorithm to define statin-related myotoxicity phenotypes, including myalgia, myopathy, rhabdomyolysis, and necrotizing autoimmune myopathy.

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Published In

Clin Pharmacol Ther

DOI

EISSN

1532-6535

Publication Date

October 2014

Volume

96

Issue

4

Start / End Page

470 / 476

Location

United States

Related Subject Headings

  • Time Factors
  • Terminology as Topic
  • Risk Factors
  • Rhabdomyolysis
  • Phenotype
  • Pharmacology & Pharmacy
  • Myositis
  • Myalgia
  • Muscular Diseases
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
 

Citation

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Alfirevic, A., Neely, D., Armitage, J., Chinoy, H., Cooper, R. G., Laaksonen, R., … Pirmohamed, M. (2014). Phenotype standardization for statin-induced myotoxicity. Clin Pharmacol Ther, 96(4), 470–476. https://doi.org/10.1038/clpt.2014.121
Alfirevic, A., D. Neely, J. Armitage, H. Chinoy, R. G. Cooper, R. Laaksonen, D. F. Carr, et al. “Phenotype standardization for statin-induced myotoxicity.Clin Pharmacol Ther 96, no. 4 (October 2014): 470–76. https://doi.org/10.1038/clpt.2014.121.
Alfirevic A, Neely D, Armitage J, Chinoy H, Cooper RG, Laaksonen R, et al. Phenotype standardization for statin-induced myotoxicity. Clin Pharmacol Ther. 2014 Oct;96(4):470–6.
Alfirevic, A., et al. “Phenotype standardization for statin-induced myotoxicity.Clin Pharmacol Ther, vol. 96, no. 4, Oct. 2014, pp. 470–76. Pubmed, doi:10.1038/clpt.2014.121.
Alfirevic A, Neely D, Armitage J, Chinoy H, Cooper RG, Laaksonen R, Carr DF, Bloch KM, Fahy J, Hanson A, Yue Q-Y, Wadelius M, Maitland-van Der Zee AH, Voora D, Psaty BM, Palmer CNA, Pirmohamed M. Phenotype standardization for statin-induced myotoxicity. Clin Pharmacol Ther. 2014 Oct;96(4):470–476.
Journal cover image

Published In

Clin Pharmacol Ther

DOI

EISSN

1532-6535

Publication Date

October 2014

Volume

96

Issue

4

Start / End Page

470 / 476

Location

United States

Related Subject Headings

  • Time Factors
  • Terminology as Topic
  • Risk Factors
  • Rhabdomyolysis
  • Phenotype
  • Pharmacology & Pharmacy
  • Myositis
  • Myalgia
  • Muscular Diseases
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors