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Update: Acute coronary syndromes (V). Personalized antiplatelet therapy.

Publication ,  Journal Article
Gurbel, PA; Rafeedheen, R; Tantry, US
Published in: Rev Esp Cardiol (Engl Ed)
June 2014

It is well established that high on-treatment platelet reactivity to adenosine diphosphate during clopidogrel therapy is an independent risk factor for ischemic event occurrences in a postpercutaneous coronary intervention patients. However, the precise role of platelet function testing remains debated. Platelet function testing to ensure optimal platelet inhibition has been recommended by some authorities to improve outcomes in patients treated with clopidogrel. Recent prospective, randomized trials of personalized antiplatelet therapy have failed to demonstrate a benefit of platelet function testing in improving outcomes. In this review article, we discuss the mechanisms responsible for clopidogrel nonreponsiveness, recent trials of platelet function testing, and other new developments in the field of personalized antiplatelet therapy.

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Published In

Rev Esp Cardiol (Engl Ed)

DOI

EISSN

1885-5857

Publication Date

June 2014

Volume

67

Issue

6

Start / End Page

480 / 487

Location

Spain

Related Subject Headings

  • Treatment Failure
  • Ticlopidine
  • Randomized Controlled Trials as Topic
  • Precision Medicine
  • Platelet Aggregation Inhibitors
  • Humans
  • Clopidogrel
  • Acute Coronary Syndrome
 

Citation

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Gurbel, P. A., Rafeedheen, R., & Tantry, U. S. (2014). Update: Acute coronary syndromes (V). Personalized antiplatelet therapy. Rev Esp Cardiol (Engl Ed), 67(6), 480–487. https://doi.org/10.1016/j.rec.2014.01.012
Gurbel, Paul A., Rahil Rafeedheen, and Udaya S. Tantry. “Update: Acute coronary syndromes (V). Personalized antiplatelet therapy.Rev Esp Cardiol (Engl Ed) 67, no. 6 (June 2014): 480–87. https://doi.org/10.1016/j.rec.2014.01.012.
Gurbel PA, Rafeedheen R, Tantry US. Update: Acute coronary syndromes (V). Personalized antiplatelet therapy. Rev Esp Cardiol (Engl Ed). 2014 Jun;67(6):480–7.
Gurbel, Paul A., et al. “Update: Acute coronary syndromes (V). Personalized antiplatelet therapy.Rev Esp Cardiol (Engl Ed), vol. 67, no. 6, June 2014, pp. 480–87. Pubmed, doi:10.1016/j.rec.2014.01.012.
Gurbel PA, Rafeedheen R, Tantry US. Update: Acute coronary syndromes (V). Personalized antiplatelet therapy. Rev Esp Cardiol (Engl Ed). 2014 Jun;67(6):480–487.
Journal cover image

Published In

Rev Esp Cardiol (Engl Ed)

DOI

EISSN

1885-5857

Publication Date

June 2014

Volume

67

Issue

6

Start / End Page

480 / 487

Location

Spain

Related Subject Headings

  • Treatment Failure
  • Ticlopidine
  • Randomized Controlled Trials as Topic
  • Precision Medicine
  • Platelet Aggregation Inhibitors
  • Humans
  • Clopidogrel
  • Acute Coronary Syndrome