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Osteoporosis Assessment Questionnaire-Physical Function (OPAQ-PF): a psychometrically validated osteoporosis-targeted patient reported outcome measure of daily activities of physical function.

Publication ,  Journal Article
Nixon, A; Kerr, C; Doll, H; Naegeli, AN; Shingler, SL; Breheny, K; Burge, R; Gold, DT; Silverman, S
Published in: Osteoporos Int
June 2014

UNLABELLED: The purpose of this study was to evaluate the measurement properties of the Osteoporosis Assessment Questionnaire-Physical Functioning (OPAQ-PF). Based on this study, the OPAQ-PF has confirmed unidimensionality and acceptable reliability, construct validity, and sensitivity to change in a recent fracture/no recent fracture osteoporosis sample. METHODS: Dimensionality was established through exploratory and confirmatory factor analysis. Patients completed three patient reported outcome (PRO) measures and four performance-based measures (PBMs) at baseline to enable an evaluation of construct validity. Patients without a recent fracture completed the OPAQ-PF 2 weeks after baseline to enable an evaluation of test-retest reliability. Ability to detect change and interpretation of change were investigated following completion of the OPAQ-PF 12 and 24 weeks postbaseline by patients with a recent fracture. RESULTS: A prospective psychometric validation study in 144 postmenopausal women, with moderate to severe osteoporosis, 37 of whom had experienced a recent fragility fracture (<6 weeks). Unidimensionality was established for the OPAQ-PF by factor analysis. The OPAQ-PF had good internal consistency (α = 0.974) and test-retest reliability (mean intraclass correlation coefficient (ICC) 0.993. The OPAQ-PF differentiated between patients with/without recent fracture, and by severity of osteoarthritis; it correlated strongly with hypothesized-related scales and PBMs (r > 0.3, p < 0.001). Ability to detect change was established with high correlations between changes in OPAQ-PF score and changes in global concept scores in recent fracture patients (r ≥ 0.6, 24-week change). Effect size of change on OPAQ-PF score increased by level of global change (p < 0.001). Anchor-based methods identified an OPAQ-PF change of 10 at an individual patient level and 20 at a group level as meaningful to patients. CONCLUSIONS: The OPAQ-PF has confirmed unidimensionality and acceptable reliability, construct validity, and sensitivity to change in a recent fracture/no recent fracture osteoporosis sample.

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Published In

Osteoporos Int

DOI

EISSN

1433-2965

Publication Date

June 2014

Volume

25

Issue

6

Start / End Page

1775 / 1784

Location

England

Related Subject Headings

  • United States
  • Surveys and Questionnaires
  • Socioeconomic Factors
  • Severity of Illness Index
  • Reproducibility of Results
  • Psychometrics
  • Prospective Studies
  • Prognosis
  • Patient Outcome Assessment
  • Osteoporotic Fractures
 

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Nixon, A., Kerr, C., Doll, H., Naegeli, A. N., Shingler, S. L., Breheny, K., … Silverman, S. (2014). Osteoporosis Assessment Questionnaire-Physical Function (OPAQ-PF): a psychometrically validated osteoporosis-targeted patient reported outcome measure of daily activities of physical function. Osteoporos Int, 25(6), 1775–1784. https://doi.org/10.1007/s00198-014-2695-4
Nixon, A., C. Kerr, H. Doll, A. N. Naegeli, S. L. Shingler, K. Breheny, R. Burge, D. T. Gold, and S. Silverman. “Osteoporosis Assessment Questionnaire-Physical Function (OPAQ-PF): a psychometrically validated osteoporosis-targeted patient reported outcome measure of daily activities of physical function.Osteoporos Int 25, no. 6 (June 2014): 1775–84. https://doi.org/10.1007/s00198-014-2695-4.
Nixon A, Kerr C, Doll H, Naegeli AN, Shingler SL, Breheny K, Burge R, Gold DT, Silverman S. Osteoporosis Assessment Questionnaire-Physical Function (OPAQ-PF): a psychometrically validated osteoporosis-targeted patient reported outcome measure of daily activities of physical function. Osteoporos Int. 2014 Jun;25(6):1775–1784.
Journal cover image

Published In

Osteoporos Int

DOI

EISSN

1433-2965

Publication Date

June 2014

Volume

25

Issue

6

Start / End Page

1775 / 1784

Location

England

Related Subject Headings

  • United States
  • Surveys and Questionnaires
  • Socioeconomic Factors
  • Severity of Illness Index
  • Reproducibility of Results
  • Psychometrics
  • Prospective Studies
  • Prognosis
  • Patient Outcome Assessment
  • Osteoporotic Fractures