Roles of collateral arterial flow and ischemic preconditioning in protection of acutely ischemic myocardium.
The extent and rate at which necrosis develops in experimental acute myocardial infarction in the dog heart is presented together with an analysis of the role played by protective mechanisms in myocyte death. Preconditioning with ischemia delays but does not prevent myocyte death. Arterial collateral flows exceeding 30% of control flow essentially prevent myocyte death, while lesser amounts of collateral flow delay myocyte death to a variable extent. Flows of <0.09mlmin(-1)g(-1) wet exert no protective effect. Cell death occurs as quickly as it does with zero flow. Electrocardiography provides a means of detection of the preconditioned state in the dog heart in that the amount of ST elevation observed during the preconditioning episode is reduced during subsequent episodes of ischemia. Also, marked depression of arterial collateral flow can be detected by an increase in the duration of the QRS segment.
Duke Scholars
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Related Subject Headings
- Myocardial Ischemia
- Models, Cardiovascular
- Ischemic Preconditioning
- Dogs
- Coronary Circulation
- Cardiovascular System & Hematology
- Blood Flow Velocity
- Animals
- Acute Disease
- 3201 Cardiovascular medicine and haematology
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Myocardial Ischemia
- Models, Cardiovascular
- Ischemic Preconditioning
- Dogs
- Coronary Circulation
- Cardiovascular System & Hematology
- Blood Flow Velocity
- Animals
- Acute Disease
- 3201 Cardiovascular medicine and haematology