Eosinophil-associated lung diseases. A cry for surfactant proteins A and D help?
Surfactant proteins (SP)-A and SP-D (SP-A/-D) play important roles in numerous eosinophil-dominated diseases, including asthma, allergic bronchopulmonary aspergillosis, and allergic rhinitis. In these settings, SP-A/-D have been shown to modulate eosinophil chemotaxis, inhibit eosinophil mediator release, and mediate macrophage clearance of apoptotic eosinophils. Dysregulation of SP-A/-D function in eosinophil-dominated diseases is also not uncommon. Alterations in serum SP-A/-D levels are associated with disease severity in allergic rhinitis and chronic obstructive pulmonary disease. Furthermore, oligimerization of SP-A/-D, necessary for their proper function, can be perturbed by reactive nitrogen species, which are increased in eosinophilic disease. In this review, we highlight the associations of eosinophilic lung diseases with SP-A and SP-D levels and functions.
Duke Scholars
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Related Subject Headings
- Respiratory System
- Pulmonary Surfactant-Associated Protein D
- Pulmonary Surfactant-Associated Protein A
- Lung Diseases
- Humans
- Eosinophils
- 3201 Cardiovascular medicine and haematology
- 3101 Biochemistry and cell biology
- 1102 Cardiorespiratory Medicine and Haematology
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Respiratory System
- Pulmonary Surfactant-Associated Protein D
- Pulmonary Surfactant-Associated Protein A
- Lung Diseases
- Humans
- Eosinophils
- 3201 Cardiovascular medicine and haematology
- 3101 Biochemistry and cell biology
- 1102 Cardiorespiratory Medicine and Haematology