Skip to main content

Future strategies for the treatment of cryptococcal meningoencephalitis in pediatric patients

Publication ,  Journal Article
Spivey, JR; Drew, RH; Perfect, JR
Published in: Expert Opinion on Orphan Drugs
January 1, 2014

Introduction: Cryptococcal meningoencephalitis (CM) is a rare infection in pediatric patients, which is associated with substantial morbidity and mortality. Since symptoms of this infection are nonspecific, the diagnosis relies on risk assessment and laboratory-confirmed clinical findings. Initial management commonly utilizes amphotericin B and flucytosine, followed by prolonged fluconazole to clear the yeast and prevent relapse. Since no prospective clinical trials have been performed in pediatric patients, much of the data are extrapolated from adult studies and pediatric pharmacokinetic data. This highlights the need for this review and additional studies. Areas covered: Here, the pathophysiology, epidemiology, presentation and treatment of CM in pediatric patients are described. Additionally, the relative safety and pharmacokinetic differences in pharmacologic treatment between pediatric and adult patients are highlighted. Expert opinion: Guidelines for the management of pediatric patients with CM are extrapolated from those for adults with HIV. Therefore, pharmacokinetic differences should be considered. Pediatric CM is a treatable disease with many children infected but rarely manifesting disease. Additionally, new advances promise to make an impact on the management and outcome of CM. New antifungal drugs are not likely to be available in the near future for CM treatment. © 2014 Informa UK, Ltd.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Expert Opinion on Orphan Drugs

DOI

EISSN

2167-8707

Publication Date

January 1, 2014

Volume

2

Issue

3

Start / End Page

245 / 257

Related Subject Headings

  • 3214 Pharmacology and pharmaceutical sciences
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Spivey, J. R., Drew, R. H., & Perfect, J. R. (2014). Future strategies for the treatment of cryptococcal meningoencephalitis in pediatric patients. Expert Opinion on Orphan Drugs, 2(3), 245–257. https://doi.org/10.1517/21678707.2014.880649
Spivey, J. R., R. H. Drew, and J. R. Perfect. “Future strategies for the treatment of cryptococcal meningoencephalitis in pediatric patients.” Expert Opinion on Orphan Drugs 2, no. 3 (January 1, 2014): 245–57. https://doi.org/10.1517/21678707.2014.880649.
Spivey JR, Drew RH, Perfect JR. Future strategies for the treatment of cryptococcal meningoencephalitis in pediatric patients. Expert Opinion on Orphan Drugs. 2014 Jan 1;2(3):245–57.
Spivey, J. R., et al. “Future strategies for the treatment of cryptococcal meningoencephalitis in pediatric patients.” Expert Opinion on Orphan Drugs, vol. 2, no. 3, Jan. 2014, pp. 245–57. Scopus, doi:10.1517/21678707.2014.880649.
Spivey JR, Drew RH, Perfect JR. Future strategies for the treatment of cryptococcal meningoencephalitis in pediatric patients. Expert Opinion on Orphan Drugs. 2014 Jan 1;2(3):245–257.

Published In

Expert Opinion on Orphan Drugs

DOI

EISSN

2167-8707

Publication Date

January 1, 2014

Volume

2

Issue

3

Start / End Page

245 / 257

Related Subject Headings

  • 3214 Pharmacology and pharmaceutical sciences
  • 3202 Clinical sciences