HPV genotypes and cervical intraepithelial Neoplasiain a multiethnic cohort in the southeastern United States

Background: For poorly understood reasons, invasive cervical cancer (ICC) incidence and mortality rates are higher in women of African descent. Oncogenic human papillomavirus (HPV) genotypes distribution may vary between European American (EA) and African American (AA) women, and may contribute to differences in ICC incidence. Methods: Five-hundred and seventy-two women were enrolled at the time of colposcopic evaluation following an abnormal liquid-based cytology screen. HPV infections were detected using HPV-linear array, and chi-squared tests and linear regression models were used to compare HPV genotypes across racial/ethnic groups by CIN status. Results: Of the 572 participants, 494 (86%) had detectable HPV; 245 (43%) had no CINlesion, 239 (42%) had CIN1, and 88 (15%) had CIN2/3. Seventy-three percent of all women were infected with multiple HPV genotypes. After adjusting for race, age, parity, oral contraception use and current smoking, AAs were two times less likely to harbor HVP16/18 (OR=0.52, 95%CI 0.27-0.98, p=0.04) when all women were considered. This association remained unchanged when only women with CIN2/3 lesions were examined (OR=0.22, 95%CI 0.05-0.95, p=0.04). The most frequent high risk (HR)-HPV genotypes detected among EAs were 16, 18, 56, 39 and 66, while HPV genotypes 33, 35, 45, 58 and 68 were the most frequent ones detected in AAs. Conclusions: Our data suggest that while HPV 16/18 are the most common genotypes among EA women with CIN, AAAAs harbor different genotypes. Impact: If results from this study are replicated in larger cohorts, they may improve risk stratification in ICC screening. © 2014 Vidal AC et al.

Duke Scholars

Author Kimberly S. Hawblitzel Yarnall Family Medicine and Community Health, Family Medicine

Author Rex Colle Bentley Pathology

Author Margaret Gradison Family Medicine and Community Health, Family Medicine

Author Anne Cunanan Ford Obstetrics and Gynecology, Duke Women's Health Wake North

Author Susan Kay Murphy Obstetrics and Gynecology, Reproductive Sciences