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Therapy of acute and fulminant hepatitis B.

Publication ,  Journal Article
Tillmann, HL; Patel, K
Published in: Intervirology
2014

Although new hepatitis B virus (HBV) infections are decreasing due to improving vaccination coverage, patients without vaccination coverage can still suffer from manifestation of acute hepatitis B with jaundice and (although rarely) liver failure. No treatment is indicated for mild acute hepatitis B; however, antiviral therapy should be initiated for patients showing signs of significant liver impairment as exemplified by deterioration of prothrombin time to an equivalent of 1.5 or 50% of the 'Quick test'. For fulminant hepatitis, there is no complete agreement on whether antiviral treatment would alter the course, but it should still be started, as it would reduce the risk of reinfection in case there is a need for liver transplantation. Patients in danger of progression towards acute liver failure should be referred to transplant centers as early as possible.

Duke Scholars

Published In

Intervirology

DOI

EISSN

1423-0100

Publication Date

2014

Volume

57

Issue

3-4

Start / End Page

181 / 188

Location

Switzerland

Related Subject Headings

  • Virology
  • Thymidine
  • Telbivudine
  • Reverse Transcriptase Inhibitors
  • Recombinant Proteins
  • Polyethylene Glycols
  • Liver Transplantation
  • Liver Failure, Acute
  • Liver
  • Lamivudine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tillmann, H. L., & Patel, K. (2014). Therapy of acute and fulminant hepatitis B. Intervirology, 57(3–4), 181–188. https://doi.org/10.1159/000360939
Tillmann, Hans L., and Keyur Patel. “Therapy of acute and fulminant hepatitis B.Intervirology 57, no. 3–4 (2014): 181–88. https://doi.org/10.1159/000360939.
Tillmann HL, Patel K. Therapy of acute and fulminant hepatitis B. Intervirology. 2014;57(3–4):181–8.
Tillmann, Hans L., and Keyur Patel. “Therapy of acute and fulminant hepatitis B.Intervirology, vol. 57, no. 3–4, 2014, pp. 181–88. Pubmed, doi:10.1159/000360939.
Tillmann HL, Patel K. Therapy of acute and fulminant hepatitis B. Intervirology. 2014;57(3–4):181–188.
Journal cover image

Published In

Intervirology

DOI

EISSN

1423-0100

Publication Date

2014

Volume

57

Issue

3-4

Start / End Page

181 / 188

Location

Switzerland

Related Subject Headings

  • Virology
  • Thymidine
  • Telbivudine
  • Reverse Transcriptase Inhibitors
  • Recombinant Proteins
  • Polyethylene Glycols
  • Liver Transplantation
  • Liver Failure, Acute
  • Liver
  • Lamivudine