Skip to main content

Correlates of osteoprotegerin and association with aortic pulse wave velocity in patients with chronic kidney disease.

Publication ,  Journal Article
Scialla, JJ; Leonard, MB; Townsend, RR; Appel, L; Wolf, M; Budoff, MJ; Chen, J; Lustigova, E; Gadegbeku, CA; Glenn, M; Hanish, A; Raj, D ...
Published in: Clin J Am Soc Nephrol
November 2011

BACKGROUND AND OBJECTIVES: Osteoprotegerin (OPG), a cytokine that regulates bone resorption, has been implicated in the process of vascular calcification and stiffness. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Serum OPG was measured in 351 participants with chronic kidney disease (CKD) from one site of the Chronic Renal Insufficiency Cohort Study. Cortical bone mineral content (BMC) was measured by quantitative computed tomography in the tibia. Multivariable linear regression was used to test the association between serum OPG and traditional cardiovascular risk factors, measures of abnormal bone and mineral metabolism, and pulse wave velocity. RESULTS: Higher serum OPG levels were associated with older age, female gender, greater systolic BP, lower estimated GFR, and lower serum albumin. OPG was not associated with measures of abnormal bone or mineral metabolism including serum phosphorus, albumin-corrected serum calcium, intact parathyroid hormone, bone-specific alkaline phosphatase, or cortical BMC. Among 226 participants with concurrent aortic pulse wave velocity measurements, increasing tertiles of serum OPG were associated with higher aortic pulse wave velocity after adjustment for demographics, traditional vascular risk factors, and nontraditional risk factors such as estimated GFR, albuminuria, serum phosphate, corrected serum calcium, presence of secondary hyperparathyroidism, serum albumin, and C-reactive protein or after additional adjustment for cortical BMC in a subset (n = 161). CONCLUSIONS: These data support a strong relationship between serum OPG and arterial stiffness independent of many potential confounders including traditional cardiovascular risk factors, abnormal bone and mineral metabolism, and inflammation.

Duke Scholars

Published In

Clin J Am Soc Nephrol

DOI

EISSN

1555-905X

Publication Date

November 2011

Volume

6

Issue

11

Start / End Page

2612 / 2619

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Up-Regulation
  • United States
  • Tomography, X-Ray Computed
  • Tibia
  • Risk Factors
  • Risk Assessment
  • Regional Blood Flow
  • Pulsatile Flow
  • Osteoprotegerin
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Scialla, J. J., Leonard, M. B., Townsend, R. R., Appel, L., Wolf, M., Budoff, M. J., … CRIC Study Group, . (2011). Correlates of osteoprotegerin and association with aortic pulse wave velocity in patients with chronic kidney disease. Clin J Am Soc Nephrol, 6(11), 2612–2619. https://doi.org/10.2215/CJN.03910411
Scialla, Julia J., Mary B. Leonard, Raymond R. Townsend, Lawrence Appel, Myles Wolf, Matt J. Budoff, Jing Chen, et al. “Correlates of osteoprotegerin and association with aortic pulse wave velocity in patients with chronic kidney disease.Clin J Am Soc Nephrol 6, no. 11 (November 2011): 2612–19. https://doi.org/10.2215/CJN.03910411.
Scialla JJ, Leonard MB, Townsend RR, Appel L, Wolf M, Budoff MJ, et al. Correlates of osteoprotegerin and association with aortic pulse wave velocity in patients with chronic kidney disease. Clin J Am Soc Nephrol. 2011 Nov;6(11):2612–9.
Scialla, Julia J., et al. “Correlates of osteoprotegerin and association with aortic pulse wave velocity in patients with chronic kidney disease.Clin J Am Soc Nephrol, vol. 6, no. 11, Nov. 2011, pp. 2612–19. Pubmed, doi:10.2215/CJN.03910411.
Scialla JJ, Leonard MB, Townsend RR, Appel L, Wolf M, Budoff MJ, Chen J, Lustigova E, Gadegbeku CA, Glenn M, Hanish A, Raj D, Rosas SE, Seliger SL, Weir MR, Parekh RS, CRIC Study Group. Correlates of osteoprotegerin and association with aortic pulse wave velocity in patients with chronic kidney disease. Clin J Am Soc Nephrol. 2011 Nov;6(11):2612–2619.

Published In

Clin J Am Soc Nephrol

DOI

EISSN

1555-905X

Publication Date

November 2011

Volume

6

Issue

11

Start / End Page

2612 / 2619

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Up-Regulation
  • United States
  • Tomography, X-Ray Computed
  • Tibia
  • Risk Factors
  • Risk Assessment
  • Regional Blood Flow
  • Pulsatile Flow
  • Osteoprotegerin