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Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies.

Publication ,  Journal Article
Gao, F; Bonsignori, M; Liao, H-X; Kumar, A; Xia, S-M; Lu, X; Cai, F; Hwang, K-K; Song, H; Zhou, T; Lynch, RM; Alam, SM; Moody, MA; Kelsoe, G ...
Published in: Cell
July 31, 2014

Development of strategies for induction of HIV-1 broadly neutralizing antibodies (bnAbs) by vaccines is a priority. Determining the steps of bnAb induction in HIV-1-infected individuals who make bnAbs is a key strategy for immunogen design. Here, we study the B cell response in a bnAb-producing individual and report cooperation between two B cell lineages to drive bnAb development. We isolated a virus-neutralizing antibody lineage that targeted an envelope region (loop D) and selected virus escape mutants that resulted in both enhanced bnAb lineage envelope binding and escape mutant neutralization-traits associated with increased B cell antigen drive. Thus, in this individual, two B cell lineages cooperated to induce the development of bnAbs. Design of vaccine immunogens that simultaneously drive both helper and broadly neutralizing B cell lineages may be important for vaccine-induced recapitulation of events that transpire during the maturation of neutralizing antibodies in HIV-1-infected individuals.

Duke Scholars

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Published In

Cell

DOI

EISSN

1097-4172

Publication Date

July 31, 2014

Volume

158

Issue

3

Start / End Page

481 / 491

Location

United States

Related Subject Headings

  • env Gene Products, Human Immunodeficiency Virus
  • Sequence Alignment
  • Mutation
  • Molecular Sequence Data
  • Models, Molecular
  • Immune Evasion
  • HIV-1
  • HIV Antibodies
  • Developmental Biology
  • B-Lymphocytes
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gao, F., Bonsignori, M., Liao, H.-X., Kumar, A., Xia, S.-M., Lu, X., … Haynes, B. F. (2014). Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies. Cell, 158(3), 481–491. https://doi.org/10.1016/j.cell.2014.06.022
Gao, Feng, Mattia Bonsignori, Hua-Xin Liao, Amit Kumar, Shi-Mao Xia, Xiaozhi Lu, Fangping Cai, et al. “Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies.Cell 158, no. 3 (July 31, 2014): 481–91. https://doi.org/10.1016/j.cell.2014.06.022.
Gao F, Bonsignori M, Liao H-X, Kumar A, Xia S-M, Lu X, et al. Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies. Cell. 2014 Jul 31;158(3):481–91.
Gao, Feng, et al. “Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies.Cell, vol. 158, no. 3, July 2014, pp. 481–91. Pubmed, doi:10.1016/j.cell.2014.06.022.
Gao F, Bonsignori M, Liao H-X, Kumar A, Xia S-M, Lu X, Cai F, Hwang K-K, Song H, Zhou T, Lynch RM, Alam SM, Moody MA, Ferrari G, Berrong M, Kelsoe G, Shaw GM, Hahn BH, Montefiori DC, Kamanga G, Cohen MS, Hraber P, Kwong PD, Korber BT, Mascola JR, Kepler TB, Haynes BF. Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies. Cell. 2014 Jul 31;158(3):481–491.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

July 31, 2014

Volume

158

Issue

3

Start / End Page

481 / 491

Location

United States

Related Subject Headings

  • env Gene Products, Human Immunodeficiency Virus
  • Sequence Alignment
  • Mutation
  • Molecular Sequence Data
  • Models, Molecular
  • Immune Evasion
  • HIV-1
  • HIV Antibodies
  • Developmental Biology
  • B-Lymphocytes