Understanding the mechanisms of action of antiangiogenic agents in metastatic colorectal cancer: a clinician's perspective.
Multiple clinical trials using bevacizumab, ziv-aflibercept, and regorafenib have recently demonstrated efficacy for patients with metastatic colorectal cancer. While the net clinical benefit of each of these therapies in the second-line and refractory disease setting appears to be similar, important distinctions exist between the agents at the pharmacodynamic, tumor microenvironment, and clinical levels. The purpose of this review is to survey the preclinical evidence regarding the mechanisms of action of these novel antiangiogenic agents and provide an overview of their respective clinical activity, while highlighting distinctions between therapies. Fundamental understanding of these distinctions may aid in clinical decisions and choice of antiangiogenic therapies.
Duke Scholars
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Related Subject Headings
- Tumor Microenvironment
- Recombinant Fusion Proteins
- Receptors, Vascular Endothelial Growth Factor
- Pyridines
- Phenylurea Compounds
- Oncology & Carcinogenesis
- Humans
- Drug Screening Assays, Antitumor
- Colorectal Neoplasms
- Clinical Trials, Phase III as Topic
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Tumor Microenvironment
- Recombinant Fusion Proteins
- Receptors, Vascular Endothelial Growth Factor
- Pyridines
- Phenylurea Compounds
- Oncology & Carcinogenesis
- Humans
- Drug Screening Assays, Antitumor
- Colorectal Neoplasms
- Clinical Trials, Phase III as Topic