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A cautionary note on the use of positivity constrained reconstructions for quantification of regional PET imaging data

Publication ,  Conference
Huang, J; Wolsztynski, E; Hawe, D; Kim, KM; Roy Choudhury, K; O'Sullivan, F
Published in: IEEE Nuclear Science Symposium Conference Record
January 1, 2013

Positively constrained maximum likelihood (ML) reconstructions in PET eliminate the negative values associated with unconstrained least squares (LS) - more commonly known as filtered back-projection (FBP). This is desirable for certain qualitative imaging tasks, however, it is not clear if there is a significant benefit for quantitative analysis of dynamic data. We consider a situation where the goal is to quantify the mean uptake in a tissue region of interest using data reconstructed with or without positivity constraints. A theoretical analysis is used to show that averaging unconstrained data is a sufficient statistic for estimation of the regional mean. This calculation casts some doubt over averaging constrained data. We use simulation sto investigate the effect of positivity constraint on mixture model analysis of dynamic data. The results show that the positivity constraint may cause bias in estimation of physiological parameters. © 2013 IEEE.

Duke Scholars

Published In

IEEE Nuclear Science Symposium Conference Record

DOI

ISSN

1095-7863

ISBN

9781479905348

Publication Date

January 1, 2013
 

Citation

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Huang, J., Wolsztynski, E., Hawe, D., Kim, K. M., Roy Choudhury, K., & O’Sullivan, F. (2013). A cautionary note on the use of positivity constrained reconstructions for quantification of regional PET imaging data. In IEEE Nuclear Science Symposium Conference Record. https://doi.org/10.1109/NSSMIC.2013.6829380
Huang, J., E. Wolsztynski, D. Hawe, K. M. Kim, K. Roy Choudhury, and F. O’Sullivan. “A cautionary note on the use of positivity constrained reconstructions for quantification of regional PET imaging data.” In IEEE Nuclear Science Symposium Conference Record, 2013. https://doi.org/10.1109/NSSMIC.2013.6829380.
Huang J, Wolsztynski E, Hawe D, Kim KM, Roy Choudhury K, O’Sullivan F. A cautionary note on the use of positivity constrained reconstructions for quantification of regional PET imaging data. In: IEEE Nuclear Science Symposium Conference Record. 2013.
Huang, J., et al. “A cautionary note on the use of positivity constrained reconstructions for quantification of regional PET imaging data.” IEEE Nuclear Science Symposium Conference Record, 2013. Scopus, doi:10.1109/NSSMIC.2013.6829380.
Huang J, Wolsztynski E, Hawe D, Kim KM, Roy Choudhury K, O’Sullivan F. A cautionary note on the use of positivity constrained reconstructions for quantification of regional PET imaging data. IEEE Nuclear Science Symposium Conference Record. 2013.

Published In

IEEE Nuclear Science Symposium Conference Record

DOI

ISSN

1095-7863

ISBN

9781479905348

Publication Date

January 1, 2013