Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.
Publication
, Journal Article
Hogan, BLM; Barkauskas, CE; Chapman, HA; Epstein, JA; Jain, R; Hsia, CCW; Niklason, L; Calle, E; Le, A; Randell, SH; Rock, J; Snitow, M ...
Published in: Cell Stem Cell
August 7, 2014
Respiratory disease is the third leading cause of death in the industrialized world. Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of extensive investigations. Recent studies have provided new information about the mechanisms driving lung development and differentiation. However, there is still much to learn about the ability of the adult respiratory system to undergo repair and to replace cells lost in response to injury and disease. This Review highlights the multiple stem/progenitor populations in different regions of the adult lung, the plasticity of their behavior in injury models, and molecular pathways that support homeostasis and repair.
Duke Scholars
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Published In
Cell Stem Cell
DOI
EISSN
1875-9777
Publication Date
August 7, 2014
Volume
15
Issue
2
Start / End Page
123 / 138
Location
United States
Related Subject Headings
- Trachea
- Tissue Engineering
- Stem Cells
- Signal Transduction
- Respiratory System
- Respiration
- Regeneration
- Pulmonary Alveoli
- Mice
- Mesoderm
Citation
APA
Chicago
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MLA
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Hogan, B. L. M., Barkauskas, C. E., Chapman, H. A., Epstein, J. A., Jain, R., Hsia, C. C. W., … Morrisey, E. E. (2014). Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell, 15(2), 123–138. https://doi.org/10.1016/j.stem.2014.07.012
Hogan, Brigid L. M., Christina E. Barkauskas, Harold A. Chapman, Jonathan A. Epstein, Rajan Jain, Connie C. W. Hsia, Laura Niklason, et al. “Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.” Cell Stem Cell 15, no. 2 (August 7, 2014): 123–38. https://doi.org/10.1016/j.stem.2014.07.012.
Hogan BLM, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CCW, et al. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell. 2014 Aug 7;15(2):123–38.
Hogan, Brigid L. M., et al. “Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.” Cell Stem Cell, vol. 15, no. 2, Aug. 2014, pp. 123–38. Pubmed, doi:10.1016/j.stem.2014.07.012.
Hogan BLM, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CCW, Niklason L, Calle E, Le A, Randell SH, Rock J, Snitow M, Krummel M, Stripp BR, Vu T, White ES, Whitsett JA, Morrisey EE. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell. 2014 Aug 7;15(2):123–138.
Published In
Cell Stem Cell
DOI
EISSN
1875-9777
Publication Date
August 7, 2014
Volume
15
Issue
2
Start / End Page
123 / 138
Location
United States
Related Subject Headings
- Trachea
- Tissue Engineering
- Stem Cells
- Signal Transduction
- Respiratory System
- Respiration
- Regeneration
- Pulmonary Alveoli
- Mice
- Mesoderm