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Clinical outcome as a function of the PR-interval-there is virtue in moderation: data from the Duke Databank for cardiovascular disease.

Publication ,  Journal Article
Holmqvist, F; Thomas, KL; Broderick, S; Ersbøll, M; Singh, D; Chiswell, K; Shaw, LK; Hegland, DD; Velazquez, EJ; Daubert, JP
Published in: Europace
June 2015

AIMS: Recently, a U-shaped association between PR-interval and the risk of developing atrial fibrillation was described, with higher risk in patients with long and short PR-intervals. Little is known regarding the association of PR-interval duration and mortality. The objective of the current study was to explore the relationship between PR-interval and major cardiovascular outcomes in patients with known coronary heart disease. METHODS AND RESULTS: Patients in sinus rhythm, undergoing coronary angiography at Duke University Medical Center between 1989 and 2010, who had significant stenosis in at least one native coronary artery, were included. Patients with arrhythmia, second- or third-degree AV-block, QRS > 120 ms were excluded. A total of 9,637 patients were included (median age 63, IQR 55-71 years, 67% men). After adjustment for relevant covariates, the risk of a CV event increased with a decreasing PR-interval (10 ms decrements) for PR-interval values <162 ms (all-cause mortality; HR 1.057, 95% CI 1.019-1.096, P = 0.0030, composite of death or stroke; HR 1.047, 95% CI 1.011-1.085, P = 0.0095 and composite of cardiovascular death or cardiovascular rehospitalization; HR 1.032, 95% CI 1.002-1.063, P = 0.0387). No statistically significant changes in the risk associated with PR-interval for values >162 ms were seen for any of the studied endpoints. CONCLUSION: In patients with coronary heart disease, a prolongation of the PR-interval was not independently associated with poor outcomes, but a PR-interval shorter than normal was associated with increased all-cause mortality and other major cardiovascular events.

Duke Scholars

Published In

Europace

DOI

EISSN

1532-2092

Publication Date

June 2015

Volume

17

Issue

6

Start / End Page

978 / 985

Location

England

Related Subject Headings

  • Stroke
  • Retrospective Studies
  • Prognosis
  • Middle Aged
  • Male
  • Kaplan-Meier Estimate
  • Humans
  • Hospitalization
  • Heart Atria
  • Female
 

Citation

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MLA
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Holmqvist, F., Thomas, K. L., Broderick, S., Ersbøll, M., Singh, D., Chiswell, K., … Daubert, J. P. (2015). Clinical outcome as a function of the PR-interval-there is virtue in moderation: data from the Duke Databank for cardiovascular disease. Europace, 17(6), 978–985. https://doi.org/10.1093/europace/euu211
Holmqvist, Fredrik, Kevin L. Thomas, Samuel Broderick, Mads Ersbøll, Devinder Singh, Karen Chiswell, Linda K. Shaw, Donald D. Hegland, Eric J. Velazquez, and James P. Daubert. “Clinical outcome as a function of the PR-interval-there is virtue in moderation: data from the Duke Databank for cardiovascular disease.Europace 17, no. 6 (June 2015): 978–85. https://doi.org/10.1093/europace/euu211.
Holmqvist F, Thomas KL, Broderick S, Ersbøll M, Singh D, Chiswell K, et al. Clinical outcome as a function of the PR-interval-there is virtue in moderation: data from the Duke Databank for cardiovascular disease. Europace. 2015 Jun;17(6):978–85.
Holmqvist, Fredrik, et al. “Clinical outcome as a function of the PR-interval-there is virtue in moderation: data from the Duke Databank for cardiovascular disease.Europace, vol. 17, no. 6, June 2015, pp. 978–85. Pubmed, doi:10.1093/europace/euu211.
Holmqvist F, Thomas KL, Broderick S, Ersbøll M, Singh D, Chiswell K, Shaw LK, Hegland DD, Velazquez EJ, Daubert JP. Clinical outcome as a function of the PR-interval-there is virtue in moderation: data from the Duke Databank for cardiovascular disease. Europace. 2015 Jun;17(6):978–985.
Journal cover image

Published In

Europace

DOI

EISSN

1532-2092

Publication Date

June 2015

Volume

17

Issue

6

Start / End Page

978 / 985

Location

England

Related Subject Headings

  • Stroke
  • Retrospective Studies
  • Prognosis
  • Middle Aged
  • Male
  • Kaplan-Meier Estimate
  • Humans
  • Hospitalization
  • Heart Atria
  • Female