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Oncolytic poliovirus immunotherapy of glioblastoma.

Publication ,  Journal Article
Gromeier, M; Dobrikova, E; Dobrikov, M; Brown, M; Bryant, J; Threatt, S; Boulton, S; Carter, K; Herndon, J; Desjardins, A; Friedman, H ...
Published in: Neuro Oncol
July 2014

With the exception of Burkitt lymphoma, almost all solid cancers are susceptible to infection with poliovirus, due to widespread ectopic expression of the poliovirus receptor, the onco-fetal cell adhesion molecule Necl5/CD155. We engineered a profoundly CNS-incompetent and genetically stable variant of polio through recombination of the cognate internal ribosomal entry site (IRES) with its counterpart from human rhinovirus type 2. The resulting PVSRIPO chimera is incapable of causing poliomyelitis or encephalitis in non-human primates or human subjects, even after high-dose intracerebral inoculation, but retains excellent cytotoxic properties in malignant cells. This is due to constitutively active signal transduction pathways via Raf-Erk MAPKs to the MAPK-interacting kinase, Mnk, and the translation apparatus.

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Published In

Neuro Oncol

DOI

EISSN

1523-5866

Publication Date

July 2014

Volume

16 Suppl 3

Start / End Page

iii41

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1109 Neurosciences
 

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Gromeier, M., Dobrikova, E., Dobrikov, M., Brown, M., Bryant, J., Threatt, S., … Bigner, D. (2014). Oncolytic poliovirus immunotherapy of glioblastoma. Neuro Oncol, 16 Suppl 3, iii41. https://doi.org/10.1093/neuonc/nou208.69
Gromeier, M., E. Dobrikova, M. Dobrikov, M. Brown, J. Bryant, S. Threatt, S. Boulton, et al. “Oncolytic poliovirus immunotherapy of glioblastoma.Neuro Oncol 16 Suppl 3 (July 2014): iii41. https://doi.org/10.1093/neuonc/nou208.69.
Gromeier M, Dobrikova E, Dobrikov M, Brown M, Bryant J, Threatt S, et al. Oncolytic poliovirus immunotherapy of glioblastoma. Neuro Oncol. 2014 Jul;16 Suppl 3:iii41.
Gromeier, M., et al. “Oncolytic poliovirus immunotherapy of glioblastoma.Neuro Oncol, vol. 16 Suppl 3, July 2014, p. iii41. Pubmed, doi:10.1093/neuonc/nou208.69.
Gromeier M, Dobrikova E, Dobrikov M, Brown M, Bryant J, Threatt S, Boulton S, Carter K, Herndon J, Desjardins A, Friedman H, Sampson J, Friedman A, Bigner D. Oncolytic poliovirus immunotherapy of glioblastoma. Neuro Oncol. 2014 Jul;16 Suppl 3:iii41.
Journal cover image

Published In

Neuro Oncol

DOI

EISSN

1523-5866

Publication Date

July 2014

Volume

16 Suppl 3

Start / End Page

iii41

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1109 Neurosciences