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Association between estimated glomerular filtration rate and clinical outcomes in patients with acute ischaemic stroke: results from China National Stroke Registry.

Publication ,  Journal Article
Wang, X; Wang, Y; Wang, C; Zhao, X; Xian, Y; Wang, D; Liu, L; Luo, Y; Liu, G; Wang, Y
Published in: Age Ageing
November 2014

BACKGROUND: the impact of estimated glomerular filtration rate (eGFR) on stroke clinical outcomes remains controversial. We examined the association between eGFR and all-cause mortality, recurrent stroke, and stroke disability in patients with acute ischaemic stroke. METHODS: we analysed 8865 patients with acute ischaemic stroke in the China National Stroke Registry (CNSR) between September 2007 and August 2008. Multivariate logistic regression analysis was used to evaluate the association between eGFR and 1-year all-cause mortality, recurrent stroke, and stroke disability. Low eGFR was defined as <45 ml/min/1.73 m(2). RESULTS: of 8865 acute ischaemic stroke patients included in the analysis, eGFR of <45 ml/min/1.73 m(2) occurred in 394 (4.4%), eGFR of 45-59 ml/min/1.73 m(2) in 675 (7.6%), eGFR of 60-89 ml/min/1.73 m(2) in 3533 (39.9%), and eGFR of ≥90 ml/min/1.73 m(2) in 4263 (48.1%) at baseline. Patients with reduced renal function were more likely to die, experience recurrent stroke or have stroke disability than patients with preserved renal function. After adjusting for both demographic and clinical risk factors, an eGFR of <45 ml/min/1.73 m(2) was independently associated with 1-year all-cause mortality (OR: 2.65; 95% CI: 1.95-3.59) and recurrent stroke (OR: 1.97; 95% CI: 1.51-2.56) but not for stroke disability defined as modified Rankin Score of 2-6 (OR: 1.26; 95% CI: 0.95-1.67). These results were consistent in stratified analyses by age, diabetes or hypertension. CONCLUSIONS: a low eGFR was associated with increased risks of all-cause mortality and recurrent stroke independent of the traditional vascular risk factors in Chinese stroke patients.

Duke Scholars

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Published In

Age Ageing

DOI

EISSN

1468-2834

Publication Date

November 2014

Volume

43

Issue

6

Start / End Page

839 / 845

Location

England

Related Subject Headings

  • Time Factors
  • Stroke
  • Risk Factors
  • Registries
  • Recurrence
  • Prognosis
  • Odds Ratio
  • Multivariate Analysis
  • Middle Aged
  • Male
 

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Wang, X., Wang, Y., Wang, C., Zhao, X., Xian, Y., Wang, D., … Liu, G. (2014). Association between estimated glomerular filtration rate and clinical outcomes in patients with acute ischaemic stroke: results from China National Stroke Registry. Age Ageing, 43(6), 839–845. https://doi.org/10.1093/ageing/afu090
Wang, Xianwei, Yilong Wang, Chunxue Wang, Xingquan Zhao, Ying Xian, David Wang, Liping Liu, Yang Luo, Gaifen Liu, and Yongjun Wang. “Association between estimated glomerular filtration rate and clinical outcomes in patients with acute ischaemic stroke: results from China National Stroke Registry.Age Ageing 43, no. 6 (November 2014): 839–45. https://doi.org/10.1093/ageing/afu090.
Wang, Xianwei, et al. “Association between estimated glomerular filtration rate and clinical outcomes in patients with acute ischaemic stroke: results from China National Stroke Registry.Age Ageing, vol. 43, no. 6, Nov. 2014, pp. 839–45. Pubmed, doi:10.1093/ageing/afu090.
Journal cover image

Published In

Age Ageing

DOI

EISSN

1468-2834

Publication Date

November 2014

Volume

43

Issue

6

Start / End Page

839 / 845

Location

England

Related Subject Headings

  • Time Factors
  • Stroke
  • Risk Factors
  • Registries
  • Recurrence
  • Prognosis
  • Odds Ratio
  • Multivariate Analysis
  • Middle Aged
  • Male