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Expression of a mitochondrial progesterone receptor in human spermatozoa correlates with a progestin-dependent increase in mitochondrial membrane potential.

Publication ,  Journal Article
Tantibhedhyangkul, J; Hawkins, KC; Dai, Q; Mu, K; Dunn, CN; Miller, SE; Price, TM
Published in: Andrology
November 2014

The hyperactivation of human spermatozoa necessary for fertilization requires a substantial increase in cellular energy production. The factors responsible for increasing cellular energy remain poorly defined. This article proposes a role for a novel mitochondrial progesterone receptor (PR-M) in modulation of mitochondrial activity. Basic science studies demonstrate a 38 kDa protein with western blot analysis, consistent with PR-M; whereas imaging studies with confocal and immunoelectron microscopy demonstrate a PR on the mitochondria. Treatment with a PR-specific progestin shows increased mitochondrial membrane potential, not related to induction of an acrosome reaction. The increase in mitochondrial membrane potential was inhibited by a specific PR antagonist, but not affected by an inhibitor to the progesterone-dependent Catsper voltage-activated channel. In conclusion, these studies suggest expression of a novel mitochondrial PR in human spermatozoa with a progestin-dependent increase in mitochondrial activity. This mechanism may serve to enhance cellular energy production as the spermatozoa traverse the female genital tract being exposed to increasing concentrations of progesterone.

Duke Scholars

Published In

Andrology

DOI

EISSN

2047-2927

Publication Date

November 2014

Volume

2

Issue

6

Start / End Page

875 / 883

Location

England

Related Subject Headings

  • Spermatozoa
  • Receptors, Progesterone
  • Progestins
  • Mitochondria
  • Microscopy, Immunoelectron
  • Microscopy, Fluorescence
  • Membrane Potential, Mitochondrial
  • Male
  • Humans
  • 3215 Reproductive medicine
 

Citation

APA
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ICMJE
MLA
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Tantibhedhyangkul, J., Hawkins, K. C., Dai, Q., Mu, K., Dunn, C. N., Miller, S. E., & Price, T. M. (2014). Expression of a mitochondrial progesterone receptor in human spermatozoa correlates with a progestin-dependent increase in mitochondrial membrane potential. Andrology, 2(6), 875–883. https://doi.org/10.1111/j.2047-2927.2014.00263.x
Tantibhedhyangkul, J., K. C. Hawkins, Q. Dai, K. Mu, C. N. Dunn, S. E. Miller, and T. M. Price. “Expression of a mitochondrial progesterone receptor in human spermatozoa correlates with a progestin-dependent increase in mitochondrial membrane potential.Andrology 2, no. 6 (November 2014): 875–83. https://doi.org/10.1111/j.2047-2927.2014.00263.x.
Tantibhedhyangkul J, Hawkins KC, Dai Q, Mu K, Dunn CN, Miller SE, et al. Expression of a mitochondrial progesterone receptor in human spermatozoa correlates with a progestin-dependent increase in mitochondrial membrane potential. Andrology. 2014 Nov;2(6):875–83.
Tantibhedhyangkul, J., et al. “Expression of a mitochondrial progesterone receptor in human spermatozoa correlates with a progestin-dependent increase in mitochondrial membrane potential.Andrology, vol. 2, no. 6, Nov. 2014, pp. 875–83. Pubmed, doi:10.1111/j.2047-2927.2014.00263.x.
Tantibhedhyangkul J, Hawkins KC, Dai Q, Mu K, Dunn CN, Miller SE, Price TM. Expression of a mitochondrial progesterone receptor in human spermatozoa correlates with a progestin-dependent increase in mitochondrial membrane potential. Andrology. 2014 Nov;2(6):875–883.
Journal cover image

Published In

Andrology

DOI

EISSN

2047-2927

Publication Date

November 2014

Volume

2

Issue

6

Start / End Page

875 / 883

Location

England

Related Subject Headings

  • Spermatozoa
  • Receptors, Progesterone
  • Progestins
  • Mitochondria
  • Microscopy, Immunoelectron
  • Microscopy, Fluorescence
  • Membrane Potential, Mitochondrial
  • Male
  • Humans
  • 3215 Reproductive medicine