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Bcl-3 acts as an innate immune modulator by controlling antimicrobial responses in keratinocytes.

Publication ,  Journal Article
Büchau, AS; MacLeod, DT; Morizane, S; Kotol, PF; Hata, T; Gallo, RL
Published in: J Invest Dermatol
September 2009

Innate immune responses involve the production of antimicrobial peptides (AMPs), chemokines, and cytokines. We report here the identification of B-cell leukemia (Bcl)-3 as a modulator of innate immune signaling in keratinocytes. In this study, it is shown that Bcl-3 is inducible by the Th2 cytokines IL-4 and IL-13 and is overexpressed in lesional skin of atopic dermatitis (AD) patients. Bcl-3 was shown to be important to cutaneous innate immune responses as silencing of Bcl-3 by small-interfering RNA (siRNA) reversed the downregulatory effect of IL-4 on the HBD3 expression. Bcl-3 silencing enhanced vitamin D3 (1,25D3)-induced gene expression of cathelicidin AMP in keratinocytes, suggesting a negative regulatory function on cathelicidin transcription. Furthermore, 1,25D3 suppressed Bcl-3 expression in vitro and in vivo. This study identified Bcl-3 as an important modulator of cutaneous innate immune responses and its possible therapeutic role in AD.

Duke Scholars

Published In

J Invest Dermatol

DOI

EISSN

1523-1747

Publication Date

September 2009

Volume

129

Issue

9

Start / End Page

2148 / 2155

Location

United States

Related Subject Headings

  • Transcription Factors
  • Proto-Oncogene Proteins
  • NF-kappa B p50 Subunit
  • Molecular Sequence Data
  • Keratinocytes
  • Interleukin-8
  • Interleukin-6
  • Interleukin-4
  • Interleukin-13
  • Immunity, Innate
 

Citation

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Büchau, A. S., MacLeod, D. T., Morizane, S., Kotol, P. F., Hata, T., & Gallo, R. L. (2009). Bcl-3 acts as an innate immune modulator by controlling antimicrobial responses in keratinocytes. J Invest Dermatol, 129(9), 2148–2155. https://doi.org/10.1038/jid.2009.49
Büchau, Amanda S., Daniel T. MacLeod, Shin Morizane, Paul F. Kotol, Tissa Hata, and Richard L. Gallo. “Bcl-3 acts as an innate immune modulator by controlling antimicrobial responses in keratinocytes.J Invest Dermatol 129, no. 9 (September 2009): 2148–55. https://doi.org/10.1038/jid.2009.49.
Büchau AS, MacLeod DT, Morizane S, Kotol PF, Hata T, Gallo RL. Bcl-3 acts as an innate immune modulator by controlling antimicrobial responses in keratinocytes. J Invest Dermatol. 2009 Sep;129(9):2148–55.
Büchau, Amanda S., et al. “Bcl-3 acts as an innate immune modulator by controlling antimicrobial responses in keratinocytes.J Invest Dermatol, vol. 129, no. 9, Sept. 2009, pp. 2148–55. Pubmed, doi:10.1038/jid.2009.49.
Büchau AS, MacLeod DT, Morizane S, Kotol PF, Hata T, Gallo RL. Bcl-3 acts as an innate immune modulator by controlling antimicrobial responses in keratinocytes. J Invest Dermatol. 2009 Sep;129(9):2148–2155.
Journal cover image

Published In

J Invest Dermatol

DOI

EISSN

1523-1747

Publication Date

September 2009

Volume

129

Issue

9

Start / End Page

2148 / 2155

Location

United States

Related Subject Headings

  • Transcription Factors
  • Proto-Oncogene Proteins
  • NF-kappa B p50 Subunit
  • Molecular Sequence Data
  • Keratinocytes
  • Interleukin-8
  • Interleukin-6
  • Interleukin-4
  • Interleukin-13
  • Immunity, Innate