Skip to main content
Journal cover image

Is diaphragm motion a good surrogate for liver tumor motion?

Publication ,  Journal Article
Yang, J; Cai, J; Wang, H; Chang, Z; Czito, BG; Bashir, MR; Palta, M; Yin, F-F
Published in: Int J Radiat Oncol Biol Phys
November 15, 2014

PURPOSE: To evaluate the relationship between liver tumor motion and diaphragm motion. METHODS AND MATERIALS: Fourteen patients with hepatocellular carcinoma (10 of 14) or liver metastases (4 of 14) undergoing radiation therapy were included in this study. All patients underwent single-slice cine-magnetic resonance imaging simulations across the center of the tumor in 3 orthogonal planes. Tumor and diaphragm motion trajectories in the superior-inferior (SI), anterior-posterior (AP), and medial-lateral (ML) directions were obtained using an in-house-developed normalized cross-correlation-based tracking technique. Agreement between the tumor and diaphragm motion was assessed by calculating phase difference percentage, intraclass correlation coefficient, and Bland-Altman analysis (Diff). The distance between the tumor and tracked diaphragm area was analyzed to understand its impact on the correlation between the 2 motions. RESULTS: Of all patients, the mean (±standard deviation) phase difference percentage values were 7.1% ± 1.1%, 4.5% ± 0.5%, and 17.5% ± 4.5% in the SI, AP, and ML directions, respectively. The mean intraclass correlation coefficient values were 0.98 ± 0.02, 0.97 ± 0.02, and 0.08 ± 0.06 in the SI, AP, and ML directions, respectively. The mean Diff values were 2.8 ± 1.4 mm, 2.4 ± 1.1 mm, and 2.2 ± 0.5 mm in the SI, AP, and ML directions, respectively. Tumor and diaphragm motions had high concordance when the distance between the tumor and tracked diaphragm area was small. CONCLUSIONS: This study showed that liver tumor motion had good correlation with diaphragm motion in the SI and AP directions, indicating diaphragm motion in the SI and AP directions could potentially be used as a reliable surrogate for liver tumor motion.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

November 15, 2014

Volume

90

Issue

4

Start / End Page

952 / 958

Location

United States

Related Subject Headings

  • Young Adult
  • Respiration
  • Oncology & Carcinogenesis
  • Movement
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging, Cine
  • Liver Neoplasms
  • Liver
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yang, J., Cai, J., Wang, H., Chang, Z., Czito, B. G., Bashir, M. R., … Yin, F.-F. (2014). Is diaphragm motion a good surrogate for liver tumor motion? Int J Radiat Oncol Biol Phys, 90(4), 952–958. https://doi.org/10.1016/j.ijrobp.2014.07.028
Yang, Juan, Jing Cai, Hongjun Wang, Zheng Chang, Brian G. Czito, Mustafa R. Bashir, Manisha Palta, and Fang-Fang Yin. “Is diaphragm motion a good surrogate for liver tumor motion?Int J Radiat Oncol Biol Phys 90, no. 4 (November 15, 2014): 952–58. https://doi.org/10.1016/j.ijrobp.2014.07.028.
Yang J, Cai J, Wang H, Chang Z, Czito BG, Bashir MR, et al. Is diaphragm motion a good surrogate for liver tumor motion? Int J Radiat Oncol Biol Phys. 2014 Nov 15;90(4):952–8.
Yang, Juan, et al. “Is diaphragm motion a good surrogate for liver tumor motion?Int J Radiat Oncol Biol Phys, vol. 90, no. 4, Nov. 2014, pp. 952–58. Pubmed, doi:10.1016/j.ijrobp.2014.07.028.
Yang J, Cai J, Wang H, Chang Z, Czito BG, Bashir MR, Palta M, Yin F-F. Is diaphragm motion a good surrogate for liver tumor motion? Int J Radiat Oncol Biol Phys. 2014 Nov 15;90(4):952–958.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

November 15, 2014

Volume

90

Issue

4

Start / End Page

952 / 958

Location

United States

Related Subject Headings

  • Young Adult
  • Respiration
  • Oncology & Carcinogenesis
  • Movement
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging, Cine
  • Liver Neoplasms
  • Liver
  • Humans