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African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles.

Publication ,  Journal Article
Roses, AD; Lutz, MW; Saunders, AM; Goldgaber, D; Saul, R; Sundseth, SS; Akkari, PA; Roses, SM; Gottschalk, WK; Whitfield, KE; Vostrov, AA ...
Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association
November 2014

Several studies have demonstrated a lower apolipoprotein E4 (APOE ε4) allele frequency in African-Americans, but yet an increased age-related prevalence of AD. An algorithm for prevention clinical trials incorporating TOMM40'523 (Translocase of Outer Mitochondria Membrane) and APOE depends on accurate TOMM40'523-APOE haplotypes.We have compared the APOE and TOMM40'523 phased haplotype frequencies of a 9.5 kb TOMM40/APOE genomic region in West African, Caucasian, and African-American cohorts.African-American haplotype frequency scans of poly-T lengths connected in phase with either APOE ε4 or APOE ε3 differ from both West Africans and Caucasians and represent admixture of several distinct West African and Caucasian haplotypes. A new West African TOMM40'523 haplotype, with APOE ε4 connected to a short TOMM40'523 allele, is observed in African-Americans but not Caucasians.These data have therapeutic implications for the age of onset risk algorithm estimates and the design of a prevention trial for African-Americans or other mixed ethnic populations.

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Published In

Alzheimer's & dementia : the journal of the Alzheimer's Association

DOI

EISSN

1552-5279

ISSN

1552-5260

Publication Date

November 2014

Volume

10

Issue

6

Start / End Page

592 / 601.e2

Related Subject Headings

  • White People
  • United States
  • Poly T
  • Mitochondrial Precursor Protein Import Complex Proteins
  • Membrane Transport Proteins
  • Male
  • Humans
  • Haplotypes
  • Geriatrics
  • Gene Frequency
 

Citation

APA
Chicago
ICMJE
MLA
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Roses, A. D., Lutz, M. W., Saunders, A. M., Goldgaber, D., Saul, R., Sundseth, S. S., … Welsh-Bohmer, K. A. (2014). African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles. Alzheimer’s & Dementia : The Journal of the Alzheimer’s Association, 10(6), 592-601.e2. https://doi.org/10.1016/j.jalz.2014.06.009
Roses, Allen D., Michael W. Lutz, Ann M. Saunders, Dmitry Goldgaber, Robert Saul, Scott S. Sundseth, P Anthony Akkari, et al. “African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles.Alzheimer’s & Dementia : The Journal of the Alzheimer’s Association 10, no. 6 (November 2014): 592-601.e2. https://doi.org/10.1016/j.jalz.2014.06.009.
Roses AD, Lutz MW, Saunders AM, Goldgaber D, Saul R, Sundseth SS, et al. African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2014 Nov;10(6):592-601.e2.
Roses, Allen D., et al. “African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles.Alzheimer’s & Dementia : The Journal of the Alzheimer’s Association, vol. 10, no. 6, Nov. 2014, pp. 592-601.e2. Epmc, doi:10.1016/j.jalz.2014.06.009.
Roses AD, Lutz MW, Saunders AM, Goldgaber D, Saul R, Sundseth SS, Akkari PA, Roses SM, Gottschalk WK, Whitfield KE, Vostrov AA, Hauser MA, Allingham RR, Burns DK, Chiba-Falek O, Welsh-Bohmer KA. African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles. Alzheimer’s & dementia : the journal of the Alzheimer’s Association. 2014 Nov;10(6):592-601.e2.
Journal cover image

Published In

Alzheimer's & dementia : the journal of the Alzheimer's Association

DOI

EISSN

1552-5279

ISSN

1552-5260

Publication Date

November 2014

Volume

10

Issue

6

Start / End Page

592 / 601.e2

Related Subject Headings

  • White People
  • United States
  • Poly T
  • Mitochondrial Precursor Protein Import Complex Proteins
  • Membrane Transport Proteins
  • Male
  • Humans
  • Haplotypes
  • Geriatrics
  • Gene Frequency