Calreticulin: roles in cell-surface protein expression.
Publication
, Journal Article
Jiang, Y; Dey, S; Matsunami, H
Published in: Membranes (Basel)
September 16, 2014
In order to perform their designated functions, proteins require precise subcellular localizations. For cell-surface proteins, such as receptors and channels, they are able to transduce signals only when properly targeted to the cell membrane. Calreticulin is a multi-functional chaperone protein involved in protein folding, maturation, and trafficking. However, evidence has been accumulating that calreticulin can also negatively regulate the surface expression of certain receptors and channels. In these instances, depletion of calreticulin enhances cell-surface expression and function. In this review, we discuss the role of calreticulin with a focus on its negative effects on the expression of cell-surface proteins.
Duke Scholars
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Published In
Membranes (Basel)
DOI
ISSN
2077-0375
Publication Date
September 16, 2014
Volume
4
Issue
3
Start / End Page
630 / 641
Location
Switzerland
Related Subject Headings
- 4011 Environmental engineering
- 4004 Chemical engineering
- 0907 Environmental Engineering
- 0905 Civil Engineering
- 0904 Chemical Engineering
Citation
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Jiang, Y., Dey, S., & Matsunami, H. (2014). Calreticulin: roles in cell-surface protein expression. Membranes (Basel), 4(3), 630–641. https://doi.org/10.3390/membranes4030630
Jiang, Yue, Sandeepa Dey, and Hiroaki Matsunami. “Calreticulin: roles in cell-surface protein expression.” Membranes (Basel) 4, no. 3 (September 16, 2014): 630–41. https://doi.org/10.3390/membranes4030630.
Jiang Y, Dey S, Matsunami H. Calreticulin: roles in cell-surface protein expression. Membranes (Basel). 2014 Sep 16;4(3):630–41.
Jiang, Yue, et al. “Calreticulin: roles in cell-surface protein expression.” Membranes (Basel), vol. 4, no. 3, Sept. 2014, pp. 630–41. Pubmed, doi:10.3390/membranes4030630.
Jiang Y, Dey S, Matsunami H. Calreticulin: roles in cell-surface protein expression. Membranes (Basel). 2014 Sep 16;4(3):630–641.
Published In
Membranes (Basel)
DOI
ISSN
2077-0375
Publication Date
September 16, 2014
Volume
4
Issue
3
Start / End Page
630 / 641
Location
Switzerland
Related Subject Headings
- 4011 Environmental engineering
- 4004 Chemical engineering
- 0907 Environmental Engineering
- 0905 Civil Engineering
- 0904 Chemical Engineering