Skip to main content
Journal cover image

Age-related differences in reporting of drug-associated liver injury: data-mining of WHO Safety Report Database.

Publication ,  Journal Article
Hunt, CM; Yuen, NA; Stirnadel-Farrant, HA; Suzuki, A
Published in: Regul Toxicol Pharmacol
November 2014

BACKGROUND/AIMS: Age-differences in the frequency and manifestations of drug-induced liver injury are not fully characterized. Data-mining analyses were performed to assess the impact of age on liver event reporting frequency with different phenotypes and agents. METHODS: 236 drugs associated with hepatotoxicity were evaluated using the Empirical Bayes Geometric Mean (EBGM) of the relative reporting ratio with 90% confidence interval (EB05 and EB95) calculated for the age groups: 0-17, 18-64, and⩾65years (or elderly), for overall, serious (acute liver failure), hepatocellular, and cholestatic liver injury, using the WHO Safety Report Database. RESULTS: Overall, cases of age 0-17, 18-64, and 65years or older comprised 6%, 62%, and 32% of liver event reports. Acute liver failure and hepatocellular injury were more frequently reported among children compared to adults and the elderly while reports with cholestatic injury were more frequent among the elderly (p<0.00001). A potential to cause mitochondrial dysfunction was more prevalent among the drugs with increased pediatric reporting frequency while high lipophilicity and biliary excretion were more common among the drugs associated with higher reporting frequency in the elderly. CONCLUSION: Age-specific phenotypes and potential drug properties associated with age-specific hepatotoxicity were identified in reported liver events; further analyses are warranted.

Duke Scholars

Published In

Regul Toxicol Pharmacol

DOI

EISSN

1096-0295

Publication Date

November 2014

Volume

70

Issue

2

Start / End Page

519 / 526

Location

Netherlands

Related Subject Headings

  • Young Adult
  • World Health Organization
  • Toxicology
  • Middle Aged
  • Liver
  • Infant, Newborn
  • Infant
  • Humans
  • Drug-Related Side Effects and Adverse Reactions
  • Databases, Factual
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hunt, C. M., Yuen, N. A., Stirnadel-Farrant, H. A., & Suzuki, A. (2014). Age-related differences in reporting of drug-associated liver injury: data-mining of WHO Safety Report Database. Regul Toxicol Pharmacol, 70(2), 519–526. https://doi.org/10.1016/j.yrtph.2014.09.007
Hunt, Christine M., Nancy A. Yuen, Heide A. Stirnadel-Farrant, and Ayako Suzuki. “Age-related differences in reporting of drug-associated liver injury: data-mining of WHO Safety Report Database.Regul Toxicol Pharmacol 70, no. 2 (November 2014): 519–26. https://doi.org/10.1016/j.yrtph.2014.09.007.
Hunt CM, Yuen NA, Stirnadel-Farrant HA, Suzuki A. Age-related differences in reporting of drug-associated liver injury: data-mining of WHO Safety Report Database. Regul Toxicol Pharmacol. 2014 Nov;70(2):519–26.
Hunt, Christine M., et al. “Age-related differences in reporting of drug-associated liver injury: data-mining of WHO Safety Report Database.Regul Toxicol Pharmacol, vol. 70, no. 2, Nov. 2014, pp. 519–26. Pubmed, doi:10.1016/j.yrtph.2014.09.007.
Hunt CM, Yuen NA, Stirnadel-Farrant HA, Suzuki A. Age-related differences in reporting of drug-associated liver injury: data-mining of WHO Safety Report Database. Regul Toxicol Pharmacol. 2014 Nov;70(2):519–526.
Journal cover image

Published In

Regul Toxicol Pharmacol

DOI

EISSN

1096-0295

Publication Date

November 2014

Volume

70

Issue

2

Start / End Page

519 / 526

Location

Netherlands

Related Subject Headings

  • Young Adult
  • World Health Organization
  • Toxicology
  • Middle Aged
  • Liver
  • Infant, Newborn
  • Infant
  • Humans
  • Drug-Related Side Effects and Adverse Reactions
  • Databases, Factual