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Myopia and age-related cataract: a systematic review and meta-analysis.

Publication ,  Journal Article
Pan, C-W; Cheng, C-Y; Saw, S-M; Wang, JJ; Wong, TY
Published in: Am J Ophthalmol
November 2013

PURPOSE: To examine if myopia is a risk factor for age-related cataract. DESIGN: Systematic review and meta-analysis. METHODS: A systematic review of the literature was performed using PubMed and Embase from their inception to March 2013 for population-based studies with data on myopia and age-related cataract, including nuclear, cortical, and posterior subcapsular (PSC) cataract. Separate meta-analyses for case-control/cross-sectional studies and cohort studies were conducted using random-effects models, with results reported as adjusted odds ratios (ORs) and relative risks (RRs), respectively. RESULTS: A total of 38 007 subjects aged 30-97 years from 12 population-based studies were included in the meta-analysis. Meta-analysis of the 7 cross-sectional studies and 1 case-control study confirmed that myopia was associated with increasingly prevalent nuclear (pooled OR 2.81, 95% CI 1.94-4.06) and PSC cataract (pooled OR 1.93, 95% CI 1.49-2.49) but not with cortical cataract (pooled OR 1.08, 95% CI 0.90-1.30). Meta-analysis from 3 or 4 cohort studies showed nonsignificant associations of myopia with incident nuclear (pooled RR 1.25, 95% CI 0.71-2.21), cortical (pooled RR 1.21, 95% CI 0.67-2.19), and PSC cataract (pooled RR 1.26, 95% CI 0.92-1.74). CONCLUSIONS: The associations of myopia with prevalent nuclear and PSC cataract are confirmed in meta-analysis of 8 study findings. The association of myopia with incidence of age-related cataract could not be confirmed in meta-analysis of 4 study findings.

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Published In

Am J Ophthalmol

DOI

EISSN

1879-1891

Publication Date

November 2013

Volume

156

Issue

5

Start / End Page

1021 / 1033.e1

Location

United States

Related Subject Headings

  • Risk Factors
  • Ophthalmology & Optometry
  • Odds Ratio
  • Myopia
  • Middle Aged
  • Incidence
  • Humans
  • Databases, Factual
  • Cross-Sectional Studies
  • Cataract
 

Citation

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Chicago
ICMJE
MLA
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Pan, C.-W., Cheng, C.-Y., Saw, S.-M., Wang, J. J., & Wong, T. Y. (2013). Myopia and age-related cataract: a systematic review and meta-analysis. Am J Ophthalmol, 156(5), 1021-1033.e1. https://doi.org/10.1016/j.ajo.2013.06.005
Pan, Chen-Wei, Ching-Yu Cheng, Seang-Mei Saw, Jie Jin Wang, and Tien Y. Wong. “Myopia and age-related cataract: a systematic review and meta-analysis.Am J Ophthalmol 156, no. 5 (November 2013): 1021-1033.e1. https://doi.org/10.1016/j.ajo.2013.06.005.
Pan C-W, Cheng C-Y, Saw S-M, Wang JJ, Wong TY. Myopia and age-related cataract: a systematic review and meta-analysis. Am J Ophthalmol. 2013 Nov;156(5):1021-1033.e1.
Pan, Chen-Wei, et al. “Myopia and age-related cataract: a systematic review and meta-analysis.Am J Ophthalmol, vol. 156, no. 5, Nov. 2013, pp. 1021-1033.e1. Pubmed, doi:10.1016/j.ajo.2013.06.005.
Pan C-W, Cheng C-Y, Saw S-M, Wang JJ, Wong TY. Myopia and age-related cataract: a systematic review and meta-analysis. Am J Ophthalmol. 2013 Nov;156(5):1021-1033.e1.
Journal cover image

Published In

Am J Ophthalmol

DOI

EISSN

1879-1891

Publication Date

November 2013

Volume

156

Issue

5

Start / End Page

1021 / 1033.e1

Location

United States

Related Subject Headings

  • Risk Factors
  • Ophthalmology & Optometry
  • Odds Ratio
  • Myopia
  • Middle Aged
  • Incidence
  • Humans
  • Databases, Factual
  • Cross-Sectional Studies
  • Cataract