Skip to main content
Journal cover image

Meniscal allograft transplantation. Part 2: systematic review of transplant timing, outcomes, return to competition, associated procedures, and prevention of osteoarthritis.

Publication ,  Journal Article
Samitier, G; Alentorn-Geli, E; Taylor, DC; Rill, B; Lock, T; Moutzouros, V; Kolowich, P
Published in: Knee Surg Sports Traumatol Arthrosc
January 2015

PURPOSE: To provide a systematic review of the literature regarding five topics in meniscal allograft transplantation (MAT): optimal timing for transplantation, outcomes, return to competition, associated procedures, and prevention of osteoarthritis. METHODS: A systematic literature search was conducted using the PubMed (MEDLINE), ScienceDirect, and EBSCO-CINAHL databases. Articles were classified only in one topic, but information contained could be reported into other topics. Information was classified according to type of study (animal, in vitro human, and in vivo human) and level of evidence (for in vivo human studies). Specific inclusion criteria were determined for the outcomes and prevention of osteoarthritis topics. RESULTS: Twenty-four studies were finally included: two optimal timing, seven outcomes, three return to competitive sport, 16 MAT and associated procedures, and 5 MAT and prevention of osteoarthritis (some studies were categorized in more than one topic). These studies corresponded to 2 animal studies and 31 in vivo human studies (1 level II, 1 level III, and 29 level IV). CONCLUSIONS: The principal conclusions were as follows: (a) there is no evidence to support that MAT has to be performed at the same time or immediately after meniscectomy to prevent development of postmeniscectomy syndrome; (b) MAT successfully improves symptoms, function, and quality of life at 7-to-14 years of follow-up (level IV evidence); (c) the overall failure rate (need for knee arthroplasty) is 10-29% at long-term follow-up; (d) MAT allows return to same level of competition in 75-85% of patients at short- to mid-term follow-up (only three studies level IV evidence with small sample size); (e) associated cartilage procedures or anterior cruciate ligament reconstruction to MAT does not worsen the results; (f) MAT may prevent progression of cartilage damaged at long-term follow-up, but may not prevent degeneration in previously healthy cartilage. LEVEL OF EVIDENCE: Systematic review of level II-IV studies, Level IV.

Duke Scholars

Published In

Knee Surg Sports Traumatol Arthrosc

DOI

EISSN

1433-7347

Publication Date

January 2015

Volume

23

Issue

1

Start / End Page

323 / 333

Location

Germany

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Homologous
  • Time Factors
  • Tibial Meniscus Injuries
  • Osteoarthritis, Knee
  • Orthopedics
  • Menisci, Tibial
  • Knee Joint
  • Knee Injuries
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Samitier, G., Alentorn-Geli, E., Taylor, D. C., Rill, B., Lock, T., Moutzouros, V., & Kolowich, P. (2015). Meniscal allograft transplantation. Part 2: systematic review of transplant timing, outcomes, return to competition, associated procedures, and prevention of osteoarthritis. Knee Surg Sports Traumatol Arthrosc, 23(1), 323–333. https://doi.org/10.1007/s00167-014-3344-3
Samitier, Gonzalo, Eduard Alentorn-Geli, Dean C. Taylor, Brian Rill, Terrence Lock, Vasilius Moutzouros, and Patricia Kolowich. “Meniscal allograft transplantation. Part 2: systematic review of transplant timing, outcomes, return to competition, associated procedures, and prevention of osteoarthritis.Knee Surg Sports Traumatol Arthrosc 23, no. 1 (January 2015): 323–33. https://doi.org/10.1007/s00167-014-3344-3.
Samitier G, Alentorn-Geli E, Taylor DC, Rill B, Lock T, Moutzouros V, et al. Meniscal allograft transplantation. Part 2: systematic review of transplant timing, outcomes, return to competition, associated procedures, and prevention of osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2015 Jan;23(1):323–33.
Samitier, Gonzalo, et al. “Meniscal allograft transplantation. Part 2: systematic review of transplant timing, outcomes, return to competition, associated procedures, and prevention of osteoarthritis.Knee Surg Sports Traumatol Arthrosc, vol. 23, no. 1, Jan. 2015, pp. 323–33. Pubmed, doi:10.1007/s00167-014-3344-3.
Samitier G, Alentorn-Geli E, Taylor DC, Rill B, Lock T, Moutzouros V, Kolowich P. Meniscal allograft transplantation. Part 2: systematic review of transplant timing, outcomes, return to competition, associated procedures, and prevention of osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2015 Jan;23(1):323–333.
Journal cover image

Published In

Knee Surg Sports Traumatol Arthrosc

DOI

EISSN

1433-7347

Publication Date

January 2015

Volume

23

Issue

1

Start / End Page

323 / 333

Location

Germany

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Homologous
  • Time Factors
  • Tibial Meniscus Injuries
  • Osteoarthritis, Knee
  • Orthopedics
  • Menisci, Tibial
  • Knee Joint
  • Knee Injuries
  • Humans