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Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection.

Publication ,  Journal Article
Ritchie, AJ; Cai, F; Smith, NMG; Chen, S; Song, H; Brackenridge, S; Abdool Karim, SS; Korber, BT; McMichael, AJ; Gao, F; Goonetilleke, N
Published in: Retrovirology
September 12, 2014

BACKGROUND: A major immune evasion mechanism of HIV-1 is the accumulation of non-synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition and virus escape. RESULTS: Here we analyze primary CD8+ T cell responses and virus escape in a HLA B*81 expressing subject who was infected with two T/F viruses from a single donor. In addition to classic escape through non-synonymous mutation/s, we also observed rapid selection of multiple recombinant viruses that conferred escape from T cells specific for two epitopes in Nef. CONCLUSIONS: Our study shows that recombination between multiple T/F viruses provide greater options for acute escape from CD8+ T cell responses than seen in cases of single T/F virus infection. This process may contribute to the rapid disease progression in patients infected by multiple T/F viruses.

Duke Scholars

Published In

Retrovirology

DOI

EISSN

1742-4690

Publication Date

September 12, 2014

Volume

11

Start / End Page

69

Location

England

Related Subject Headings

  • Virus Replication
  • Virology
  • Recombination, Genetic
  • Male
  • Immune Evasion
  • Humans
  • HIV-1
  • HIV Infections
  • CD8-Positive T-Lymphocytes
  • Adult
 

Citation

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Ritchie, A. J., Cai, F., Smith, N. M. G., Chen, S., Song, H., Brackenridge, S., … Goonetilleke, N. (2014). Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection. Retrovirology, 11, 69. https://doi.org/10.1186/s12977-014-0069-9
Ritchie, Adam John, Fangping Cai, Nicola M. G. Smith, Sheri Chen, Hongshuo Song, Simon Brackenridge, Salim S. Abdool Karim, et al. “Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection.Retrovirology 11 (September 12, 2014): 69. https://doi.org/10.1186/s12977-014-0069-9.
Ritchie AJ, Cai F, Smith NMG, Chen S, Song H, Brackenridge S, et al. Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection. Retrovirology. 2014 Sep 12;11:69.
Ritchie, Adam John, et al. “Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection.Retrovirology, vol. 11, Sept. 2014, p. 69. Pubmed, doi:10.1186/s12977-014-0069-9.
Ritchie AJ, Cai F, Smith NMG, Chen S, Song H, Brackenridge S, Abdool Karim SS, Korber BT, McMichael AJ, Gao F, Goonetilleke N. Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection. Retrovirology. 2014 Sep 12;11:69.
Journal cover image

Published In

Retrovirology

DOI

EISSN

1742-4690

Publication Date

September 12, 2014

Volume

11

Start / End Page

69

Location

England

Related Subject Headings

  • Virus Replication
  • Virology
  • Recombination, Genetic
  • Male
  • Immune Evasion
  • Humans
  • HIV-1
  • HIV Infections
  • CD8-Positive T-Lymphocytes
  • Adult