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Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics.

Publication ,  Journal Article
Kim, D-H; Viventi, J; Amsden, JJ; Xiao, J; Vigeland, L; Kim, Y-S; Blanco, JA; Panilaitis, B; Frechette, ES; Contreras, D; Kaplan, DL; Huang, Y ...
Published in: Nature materials
June 2010

Electronics that are capable of intimate, non-invasive integration with the soft, curvilinear surfaces of biological tissues offer important opportunities for diagnosing and treating disease and for improving brain/machine interfaces. This article describes a material strategy for a type of bio-interfaced system that relies on ultrathin electronics supported by bioresorbable substrates of silk fibroin. Mounting such devices on tissue and then allowing the silk to dissolve and resorb initiates a spontaneous, conformal wrapping process driven by capillary forces at the biotic/abiotic interface. Specialized mesh designs and ultrathin forms for the electronics ensure minimal stresses on the tissue and highly conformal coverage, even for complex curvilinear surfaces, as confirmed by experimental and theoretical studies. In vivo, neural mapping experiments on feline animal models illustrate one mode of use for this class of technology. These concepts provide new capabilities for implantable and surgical devices.

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Published In

Nature materials

DOI

EISSN

1476-4660

ISSN

1476-1122

Publication Date

June 2010

Volume

9

Issue

6

Start / End Page

511 / 517

Related Subject Headings

  • Surgical Instruments
  • Stress, Mechanical
  • Solubility
  • Silk
  • Prostheses and Implants
  • Polymethyl Methacrylate
  • Nanoscience & Nanotechnology
  • Models, Animal
  • Microscopy, Confocal
  • Fibroins
 

Citation

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Kim, D.-H., Viventi, J., Amsden, J. J., Xiao, J., Vigeland, L., Kim, Y.-S., … Rogers, J. A. (2010). Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics. Nature Materials, 9(6), 511–517. https://doi.org/10.1038/nmat2745
Kim, Dae-Hyeong, Jonathan Viventi, Jason J. Amsden, Jianliang Xiao, Leif Vigeland, Yun-Soung Kim, Justin A. Blanco, et al. “Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics.Nature Materials 9, no. 6 (June 2010): 511–17. https://doi.org/10.1038/nmat2745.
Kim D-H, Viventi J, Amsden JJ, Xiao J, Vigeland L, Kim Y-S, et al. Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics. Nature materials. 2010 Jun;9(6):511–7.
Kim, Dae-Hyeong, et al. “Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics.Nature Materials, vol. 9, no. 6, June 2010, pp. 511–17. Epmc, doi:10.1038/nmat2745.
Kim D-H, Viventi J, Amsden JJ, Xiao J, Vigeland L, Kim Y-S, Blanco JA, Panilaitis B, Frechette ES, Contreras D, Kaplan DL, Omenetto FG, Huang Y, Hwang K-C, Zakin MR, Litt B, Rogers JA. Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics. Nature materials. 2010 Jun;9(6):511–517.

Published In

Nature materials

DOI

EISSN

1476-4660

ISSN

1476-1122

Publication Date

June 2010

Volume

9

Issue

6

Start / End Page

511 / 517

Related Subject Headings

  • Surgical Instruments
  • Stress, Mechanical
  • Solubility
  • Silk
  • Prostheses and Implants
  • Polymethyl Methacrylate
  • Nanoscience & Nanotechnology
  • Models, Animal
  • Microscopy, Confocal
  • Fibroins