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Primary prevention implantable cardioverter defibrillators in end-stage kidney disease patients on dialysis: a matched cohort study.

Publication ,  Journal Article
Pun, PH; Hellkamp, AS; Sanders, GD; Middleton, JP; Hammill, SC; Al-Khalidi, HR; Curtis, LH; Fonarow, GC; Al-Khatib, SM
Published in: Nephrol Dial Transplant
May 2015

BACKGROUND: Sudden cardiac death is the leading cause of death among end-stage kidney disease patients (ESKD) on dialysis, but the benefit of primary prevention implantable cardioverter defibrillators (ICDs) in this population is uncertain. We conducted this investigation to compare the mortality of dialysis patients receiving a primary prevention ICD with matched controls. METHODS: We used data from the National Cardiovascular Data Registry's ICD Registry to select dialysis patients who received a primary prevention ICD, and the Get with the Guidelines-Heart Failure Registry to select a comparator cohort. We matched ICD recipients and no-ICD patients using propensity score techniques to reduce confounding, and overall survival was compared between groups. RESULTS: We identified 108 dialysis patients receiving primary prevention ICDs and 195 comparable dialysis patients without ICDs. One year (3-year) mortality was 42.2% (68.8%) in the ICD registry cohort compared with 38.1% (75.7%) in the control cohort. There was no significant survival advantage associated with ICD [hazard ratio (HR) 0.87, 95% confidence interval (CI) 0.66-1.13, log-rank P = 0.29]. After propensity matching, our analysis included 86 ICD patients and 86 matched controls. Comparing the propensity-matched cohorts, 1 year (3 years) mortality was 43.4% (74.0%) in the ICD cohort and 39.7% (76.6%) in the control cohort; there was no significant difference in mortality outcome between groups (HR = 0.94, 95% CI: 0.67-1.31, log-rank P = 0.71). CONCLUSIONS: We did not observe a significant association between primary prevention ICDs and reduced mortality among ESKD patients receiving dialysis. Consideration of the potential risks and benefits of ICD implantation in these patients should be undertaken while awaiting the results of definitive clinical trials.

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Published In

Nephrol Dial Transplant

DOI

EISSN

1460-2385

Publication Date

May 2015

Volume

30

Issue

5

Start / End Page

829 / 835

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Retrospective Studies
  • Renal Dialysis
  • Registries
  • Proportional Hazards Models
  • Propensity Score
  • Primary Prevention
  • Middle Aged
  • Male
  • Kidney Failure, Chronic
 

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Pun, P. H., Hellkamp, A. S., Sanders, G. D., Middleton, J. P., Hammill, S. C., Al-Khalidi, H. R., … Al-Khatib, S. M. (2015). Primary prevention implantable cardioverter defibrillators in end-stage kidney disease patients on dialysis: a matched cohort study. Nephrol Dial Transplant, 30(5), 829–835. https://doi.org/10.1093/ndt/gfu274
Pun, Patrick H., Anne S. Hellkamp, Gillian D. Sanders, John P. Middleton, Stephen C. Hammill, Hussein R. Al-Khalidi, Lesley H. Curtis, Gregg C. Fonarow, and Sana M. Al-Khatib. “Primary prevention implantable cardioverter defibrillators in end-stage kidney disease patients on dialysis: a matched cohort study.Nephrol Dial Transplant 30, no. 5 (May 2015): 829–35. https://doi.org/10.1093/ndt/gfu274.
Pun PH, Hellkamp AS, Sanders GD, Middleton JP, Hammill SC, Al-Khalidi HR, et al. Primary prevention implantable cardioverter defibrillators in end-stage kidney disease patients on dialysis: a matched cohort study. Nephrol Dial Transplant. 2015 May;30(5):829–35.
Pun, Patrick H., et al. “Primary prevention implantable cardioverter defibrillators in end-stage kidney disease patients on dialysis: a matched cohort study.Nephrol Dial Transplant, vol. 30, no. 5, May 2015, pp. 829–35. Pubmed, doi:10.1093/ndt/gfu274.
Pun PH, Hellkamp AS, Sanders GD, Middleton JP, Hammill SC, Al-Khalidi HR, Curtis LH, Fonarow GC, Al-Khatib SM. Primary prevention implantable cardioverter defibrillators in end-stage kidney disease patients on dialysis: a matched cohort study. Nephrol Dial Transplant. 2015 May;30(5):829–835.
Journal cover image

Published In

Nephrol Dial Transplant

DOI

EISSN

1460-2385

Publication Date

May 2015

Volume

30

Issue

5

Start / End Page

829 / 835

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Retrospective Studies
  • Renal Dialysis
  • Registries
  • Proportional Hazards Models
  • Propensity Score
  • Primary Prevention
  • Middle Aged
  • Male
  • Kidney Failure, Chronic