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Clinical outcomes of splenectomy in children: report of the splenectomy in congenital hemolytic anemia registry.

Publication ,  Journal Article
Rice, HE; Englum, BR; Rothman, J; Leonard, S; Reiter, A; Thornburg, C; Brindle, M; Wright, N; Heeney, MM; Smithers, C; Brown, RL; Kalfa, T ...
Published in: Am J Hematol
March 2015

The outcomes of children with congenital hemolytic anemia (CHA) undergoing total splenectomy (TS) or partial splenectomy (PS) remain unclear. In this study, we collected data from 100 children with CHA who underwent TS or PS from 2005 to 2013 at 16 sites in the Splenectomy in Congenital Hemolytic Anemia (SICHA) consortium using a patient registry. We analyzed demographics and baseline clinical status, operative details, and outcomes at 4, 24, and 52 weeks after surgery. Results were summarized as hematologic outcomes, short-term adverse events (AEs) (≤30 days after surgery), and long-term AEs (31-365 days after surgery). For children with hereditary spherocytosis, after surgery there was an increase in hemoglobin (baseline 10.1 ± 1.8 g/dl, 52 week 12.8 ± 1.6 g/dl; mean ± SD), decrease in reticulocyte and bilirubin as well as control of symptoms. Children with sickle cell disease had control of clinical symptoms after surgery, but had no change in hematologic parameters. There was an 11% rate of short-term AEs and 11% rate of long-term AEs. As we accumulate more subjects and longer follow-up, use of a patient registry should enhance our capacity for clinical trials and engage all stakeholders in the decision-making process.

Duke Scholars

Published In

Am J Hematol

DOI

EISSN

1096-8652

Publication Date

March 2015

Volume

90

Issue

3

Start / End Page

187 / 192

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Splenectomy
  • Spherocytosis, Hereditary
  • Reticulocytes
  • Respiratory Tract Infections
  • Registries
  • Postoperative Complications
  • Male
  • Immunology
 

Citation

APA
Chicago
ICMJE
MLA
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Rice, H. E., Englum, B. R., Rothman, J., Leonard, S., Reiter, A., Thornburg, C., … Splenectomy in Congenital Hemolytic Anemia (SICHA) Consortium, . (2015). Clinical outcomes of splenectomy in children: report of the splenectomy in congenital hemolytic anemia registry. Am J Hematol, 90(3), 187–192. https://doi.org/10.1002/ajh.23888
Rice, Henry E., Brian R. Englum, Jennifer Rothman, Sarah Leonard, Audra Reiter, Courtney Thornburg, Mary Brindle, et al. “Clinical outcomes of splenectomy in children: report of the splenectomy in congenital hemolytic anemia registry.Am J Hematol 90, no. 3 (March 2015): 187–92. https://doi.org/10.1002/ajh.23888.
Rice HE, Englum BR, Rothman J, Leonard S, Reiter A, Thornburg C, et al. Clinical outcomes of splenectomy in children: report of the splenectomy in congenital hemolytic anemia registry. Am J Hematol. 2015 Mar;90(3):187–92.
Rice, Henry E., et al. “Clinical outcomes of splenectomy in children: report of the splenectomy in congenital hemolytic anemia registry.Am J Hematol, vol. 90, no. 3, Mar. 2015, pp. 187–92. Pubmed, doi:10.1002/ajh.23888.
Rice HE, Englum BR, Rothman J, Leonard S, Reiter A, Thornburg C, Brindle M, Wright N, Heeney MM, Smithers C, Brown RL, Kalfa T, Langer JC, Cada M, Oldham KT, Scott JP, St Peter S, Sharma M, Davidoff AM, Nottage K, Bernabe K, Wilson DB, Dutta S, Glader B, Crary SE, Dassinger MS, Dunbar L, Islam S, Kumar M, Rescorla F, Bruch S, Campbell A, Austin M, Sidonio R, Blakely ML, Splenectomy in Congenital Hemolytic Anemia (SICHA) Consortium. Clinical outcomes of splenectomy in children: report of the splenectomy in congenital hemolytic anemia registry. Am J Hematol. 2015 Mar;90(3):187–192.
Journal cover image

Published In

Am J Hematol

DOI

EISSN

1096-8652

Publication Date

March 2015

Volume

90

Issue

3

Start / End Page

187 / 192

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Splenectomy
  • Spherocytosis, Hereditary
  • Reticulocytes
  • Respiratory Tract Infections
  • Registries
  • Postoperative Complications
  • Male
  • Immunology