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A functional polymorphism in the HTR2C gene associated with stress responses: a validation study.

Publication ,  Journal Article
Brummett, BH; Babyak, MA; Kuhn, CM; Siegler, IC; Williams, RB
Published in: Biol Psychol
December 2014

Previously we have shown that a functional nonsynonymous single nucleotide polymorphism (SNP), rs6318 on the HTR2C gene located on the X-chromosome, is associated with hypothalamic-pituitary-adrenal axis response to a laboratory stress recall task. The present paper reports a validation of the cortisol response to stress in a second, independent sample. The study population consisted of 60 adult participants (73.3% males). Consistent with our prior findings, compared to Cys23 G allele carriers, persons homozygous for the Ser23C allele had a significantly greater average cortisol response (p=0.007) and area under the curve (p=0.021) over the course of an emotional stress recall protocol. Also parallel to our prior report, the change in cortisol from baseline to the average during the stress protocol was roughly twice as large among Ser23C homozygotes than among persons with Cys23 G. These findings validate our initial observation of association between rs6318 and cortisol response to an acute stressor, and extend the results to include females.

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Published In

Biol Psychol

DOI

EISSN

1873-6246

Publication Date

December 2014

Volume

103

Start / End Page

317 / 321

Location

Netherlands

Related Subject Headings

  • Stress, Psychological
  • Receptor, Serotonin, 5-HT2C
  • Polymorphism, Single Nucleotide
  • Pituitary-Adrenal System
  • Male
  • Hypothalamo-Hypophyseal System
  • Hydrocortisone
  • Humans
  • Genetic Association Studies
  • Female
 

Citation

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Chicago
ICMJE
MLA
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Brummett, B. H., Babyak, M. A., Kuhn, C. M., Siegler, I. C., & Williams, R. B. (2014). A functional polymorphism in the HTR2C gene associated with stress responses: a validation study. Biol Psychol, 103, 317–321. https://doi.org/10.1016/j.biopsycho.2014.10.006
Brummett, Beverly H., Michael A. Babyak, Cynthia M. Kuhn, Ilene C. Siegler, and Redford B. Williams. “A functional polymorphism in the HTR2C gene associated with stress responses: a validation study.Biol Psychol 103 (December 2014): 317–21. https://doi.org/10.1016/j.biopsycho.2014.10.006.
Brummett BH, Babyak MA, Kuhn CM, Siegler IC, Williams RB. A functional polymorphism in the HTR2C gene associated with stress responses: a validation study. Biol Psychol. 2014 Dec;103:317–21.
Brummett, Beverly H., et al. “A functional polymorphism in the HTR2C gene associated with stress responses: a validation study.Biol Psychol, vol. 103, Dec. 2014, pp. 317–21. Pubmed, doi:10.1016/j.biopsycho.2014.10.006.
Brummett BH, Babyak MA, Kuhn CM, Siegler IC, Williams RB. A functional polymorphism in the HTR2C gene associated with stress responses: a validation study. Biol Psychol. 2014 Dec;103:317–321.
Journal cover image

Published In

Biol Psychol

DOI

EISSN

1873-6246

Publication Date

December 2014

Volume

103

Start / End Page

317 / 321

Location

Netherlands

Related Subject Headings

  • Stress, Psychological
  • Receptor, Serotonin, 5-HT2C
  • Polymorphism, Single Nucleotide
  • Pituitary-Adrenal System
  • Male
  • Hypothalamo-Hypophyseal System
  • Hydrocortisone
  • Humans
  • Genetic Association Studies
  • Female