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HDAC4 promotes Pax7-dependent satellite cell activation and muscle regeneration.

Publication ,  Journal Article
Choi, M-C; Ryu, S; Hao, R; Wang, B; Kapur, M; Fan, C-M; Yao, T-P
Published in: EMBO Rep
November 2014

During muscle regeneration, the transcription factor Pax7 stimulates the differentiation of satellite cells (SCs) toward the muscle lineage but restricts adipogenesis. Here, we identify HDAC4 as a regulator of Pax7-dependent muscle regeneration. In HDAC4-deficient SCs, the expression of Pax7 and its target genes is reduced. We identify HDAC4-regulated Lix1 as a Pax7 target gene required for SC proliferation. HDAC4 inactivation leads to defective SC proliferation, muscle regeneration, and aberrant lipid accumulation. Further, expression of the brown adipose master regulator Prdm16 and its inhibitory microRNA-133 are also deregulated. Thus, HDAC4 is a novel regulator of Pax7-dependent SC proliferation and potentially fate determination in regenerating muscle.

Duke Scholars

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Published In

EMBO Rep

DOI

EISSN

1469-3178

Publication Date

November 2014

Volume

15

Issue

11

Start / End Page

1175 / 1183

Location

England

Related Subject Headings

  • Transcription Factors
  • Satellite Cells, Skeletal Muscle
  • Regeneration
  • Proteins
  • PAX7 Transcription Factor
  • Muscle, Skeletal
  • MicroRNAs
  • Mice
  • Lipid Metabolism
  • Histone Deacetylases
 

Citation

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Choi, M.-C., Ryu, S., Hao, R., Wang, B., Kapur, M., Fan, C.-M., & Yao, T.-P. (2014). HDAC4 promotes Pax7-dependent satellite cell activation and muscle regeneration. EMBO Rep, 15(11), 1175–1183. https://doi.org/10.15252/embr.201439195
Choi, Moon-Chang, Soyoung Ryu, Rui Hao, Bin Wang, Meghan Kapur, Chen-Ming Fan, and Tso-Pang Yao. “HDAC4 promotes Pax7-dependent satellite cell activation and muscle regeneration.EMBO Rep 15, no. 11 (November 2014): 1175–83. https://doi.org/10.15252/embr.201439195.
Choi M-C, Ryu S, Hao R, Wang B, Kapur M, Fan C-M, et al. HDAC4 promotes Pax7-dependent satellite cell activation and muscle regeneration. EMBO Rep. 2014 Nov;15(11):1175–83.
Choi, Moon-Chang, et al. “HDAC4 promotes Pax7-dependent satellite cell activation and muscle regeneration.EMBO Rep, vol. 15, no. 11, Nov. 2014, pp. 1175–83. Pubmed, doi:10.15252/embr.201439195.
Choi M-C, Ryu S, Hao R, Wang B, Kapur M, Fan C-M, Yao T-P. HDAC4 promotes Pax7-dependent satellite cell activation and muscle regeneration. EMBO Rep. 2014 Nov;15(11):1175–1183.
Journal cover image

Published In

EMBO Rep

DOI

EISSN

1469-3178

Publication Date

November 2014

Volume

15

Issue

11

Start / End Page

1175 / 1183

Location

England

Related Subject Headings

  • Transcription Factors
  • Satellite Cells, Skeletal Muscle
  • Regeneration
  • Proteins
  • PAX7 Transcription Factor
  • Muscle, Skeletal
  • MicroRNAs
  • Mice
  • Lipid Metabolism
  • Histone Deacetylases