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A nomogram to predict disease-free survival after surgical resection of GIST.

Publication ,  Journal Article
Bischof, DA; Kim, Y; Behman, R; Karanicolas, PJ; Quereshy, FA; Blazer, DG; Maithel, SK; Gamblin, TC; Bauer, TW; Pawlik, TM
Published in: J Gastrointest Surg
December 2014

BACKGROUND: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Adjuvant imatinib therapy has resulted in improved disease-free survival (DFS) following resection of primary GIST. The aim of our study was to create a nomogram to predict DFS following resection of GIST. METHOD: Using a multi-institutional cohort of patients who underwent surgery for primary GIST at 7 academic hospitals in the USA and Canada between January 1998 and December 2012, a multivariable Cox proportional hazards model predicting DFS was created using backward stepwise selection. A nomogram to predict DFS following surgical resection of GIST was constructed with the variables selected in the multivariable model. We tested nomogram discrimination by calculating the C-statistic and compared the nomogram to four existing GIST prognostic stratification systems. RESULTS: A total of 365 patients who underwent surgery for primary GIST was included in the study. Using backward stepwise selection, sex, tumor size, tumor site, and mitotic rate were selected for incorporation into the nomogram. The nomogram demonstrated superior discrimination compared to the NIH criteria, modified NIH criteria, and Memorial Sloan-Kettering Nomogram and had similar discrimination to the Miettinen criteria (C-statistic 0.77 vs 0.73, 0.71, 0.71, and 0.78, respectively). CONCLUSION: Four independent predictors of recurrence following surgery for primary GIST were used to create a nomogram to predict DFS. The nomogram stratified patients into prognostic groups and performed well on internal validation.

Published In

J Gastrointest Surg

DOI

EISSN

1873-4626

Publication Date

December 2014

Volume

18

Issue

12

Start / End Page

2123 / 2129

Location

Netherlands

Related Subject Headings

  • United States
  • Surgery
  • Retrospective Studies
  • Nomograms
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Incidence
  • Humans
  • Gastrointestinal Stromal Tumors
 

Citation

APA
Chicago
ICMJE
MLA
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Bischof, D. A., Kim, Y., Behman, R., Karanicolas, P. J., Quereshy, F. A., Blazer, D. G., … Pawlik, T. M. (2014). A nomogram to predict disease-free survival after surgical resection of GIST. J Gastrointest Surg, 18(12), 2123–2129. https://doi.org/10.1007/s11605-014-2658-2
Bischof, Danielle A., Yuhree Kim, Ramy Behman, Paul J. Karanicolas, Fayez A. Quereshy, Dan G. Blazer, Shishir K. Maithel, T Clark Gamblin, Todd W. Bauer, and Timothy M. Pawlik. “A nomogram to predict disease-free survival after surgical resection of GIST.J Gastrointest Surg 18, no. 12 (December 2014): 2123–29. https://doi.org/10.1007/s11605-014-2658-2.
Bischof DA, Kim Y, Behman R, Karanicolas PJ, Quereshy FA, Blazer DG, et al. A nomogram to predict disease-free survival after surgical resection of GIST. J Gastrointest Surg. 2014 Dec;18(12):2123–9.
Bischof, Danielle A., et al. “A nomogram to predict disease-free survival after surgical resection of GIST.J Gastrointest Surg, vol. 18, no. 12, Dec. 2014, pp. 2123–29. Pubmed, doi:10.1007/s11605-014-2658-2.
Bischof DA, Kim Y, Behman R, Karanicolas PJ, Quereshy FA, Blazer DG, Maithel SK, Gamblin TC, Bauer TW, Pawlik TM. A nomogram to predict disease-free survival after surgical resection of GIST. J Gastrointest Surg. 2014 Dec;18(12):2123–2129.
Journal cover image

Published In

J Gastrointest Surg

DOI

EISSN

1873-4626

Publication Date

December 2014

Volume

18

Issue

12

Start / End Page

2123 / 2129

Location

Netherlands

Related Subject Headings

  • United States
  • Surgery
  • Retrospective Studies
  • Nomograms
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Incidence
  • Humans
  • Gastrointestinal Stromal Tumors