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Patterns of failure for stage I ampulla of Vater adenocarcinoma: a single institutional experience.

Publication ,  Journal Article
Zhong, J; Palta, M; Willett, CG; McCall, SJ; McSherry, F; Tyler, DS; Uronis, HE; Czito, BG
Published in: J Gastrointest Oncol
December 2014

BACKGROUND: Ampullary adenocarcinoma is a rare malignancy associated with a relatively favorable prognosis. Given high survival rates in stage I patients reported in small series with surgery alone, adjuvant chemoradiotherapy (CRT) has traditionally been recommended only for patients with high risk disease. Recent population-based data have demonstrated inferior outcomes to previous series. We examined disease-related outcomes for stage I tumors treated with pancreaticoduodenectomy, with and without CRT. METHODS: All patients with stage I ampullary adenocarcinoma treated from 1976 to 2011 at Duke University were reviewed. Disease-related endpoints including local control (LC), metastasis-free survival (MFS), disease-free survival (DFS) and overall survival (OS) were analyzed using the Kaplan-Meier method. RESULTS: Forty-four patients were included in this study. Thirty-one patients underwent surgery alone, while 13 also received adjuvant CRT. Five-year LC, MFS, DFS and OS for patients treated with surgery only and surgery with CRT were 56% and 83% (P=0.13), 67% and 83% (P=0.31), 56% and 83% (P=0.13), and 53% and 68% (P=0.09), respectively. CONCLUSIONS: The prognosis for patients diagnosed with stage I ampullary adenocarcinoma may not be as favorable as previously described. Our data suggests a possible benefit of adjuvant CRT delivery.

Duke Scholars

Published In

J Gastrointest Oncol

DOI

ISSN

2078-6891

Publication Date

December 2014

Volume

5

Issue

6

Start / End Page

421 / 427

Location

China

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhong, J., Palta, M., Willett, C. G., McCall, S. J., McSherry, F., Tyler, D. S., … Czito, B. G. (2014). Patterns of failure for stage I ampulla of Vater adenocarcinoma: a single institutional experience. J Gastrointest Oncol, 5(6), 421–427. https://doi.org/10.3978/j.issn.2078-6891.2014.084
Zhong, Jim, Manisha Palta, Christopher G. Willett, Shannon J. McCall, Frances McSherry, Douglas S. Tyler, Hope E. Uronis, and Brian G. Czito. “Patterns of failure for stage I ampulla of Vater adenocarcinoma: a single institutional experience.J Gastrointest Oncol 5, no. 6 (December 2014): 421–27. https://doi.org/10.3978/j.issn.2078-6891.2014.084.
Zhong J, Palta M, Willett CG, McCall SJ, McSherry F, Tyler DS, et al. Patterns of failure for stage I ampulla of Vater adenocarcinoma: a single institutional experience. J Gastrointest Oncol. 2014 Dec;5(6):421–7.
Zhong, Jim, et al. “Patterns of failure for stage I ampulla of Vater adenocarcinoma: a single institutional experience.J Gastrointest Oncol, vol. 5, no. 6, Dec. 2014, pp. 421–27. Pubmed, doi:10.3978/j.issn.2078-6891.2014.084.
Zhong J, Palta M, Willett CG, McCall SJ, McSherry F, Tyler DS, Uronis HE, Czito BG. Patterns of failure for stage I ampulla of Vater adenocarcinoma: a single institutional experience. J Gastrointest Oncol. 2014 Dec;5(6):421–427.

Published In

J Gastrointest Oncol

DOI

ISSN

2078-6891

Publication Date

December 2014

Volume

5

Issue

6

Start / End Page

421 / 427

Location

China

Related Subject Headings

  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences