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The association of chronic lung disease with early mortality and respiratory adverse events after aortic valve replacement.

Publication ,  Journal Article
Crestanello, JA; Higgins, RSD; He, X; Saha-Chaudhuri, P; Englum, BR; Brennan, JM; Thourani, VH
Published in: Ann Thorac Surg
December 2014

BACKGROUND: We studied the association between components of chronic lung disease (CLD) assessment and operative outcomes in patients undergoing aortic valve replacement (AVR) for aortic stenosis. METHODS: From 2011 to 2012, 9,177 patients included in The Society of Thoracic Surgeons (STS) Cardiac Surgery Database underwent AVR for aortic stenosis with complete pulmonary function tests (PFT) and CLD data (31% of AVRs). We evaluated markers of CLD and their association with operative mortality, pulmonary morbidity, and length of hospital stay using multivariable logistic regression analysis. RESULTS: In a selected population of AVR patients with PFTs, CLD was prevalent in 50% (mild, 25.6%; moderate, 13.2%; severe, 11.2%). Predicted forced expiratory volume in 1 second (FEV1) was obtained in all patients and diffusion capacity of the lung for carbon monoxide (DLCO), arterial oxygen tension (PaO2), and arterial carbon dioxide tension (PaCO2) in 31%. The STS predicted risk of operative mortality, mortality, pulmonary morbidity, and hospital stay increased with severity of CLD and with low FEV1, DLCO, and PaO2. Moderate and severe CLD were independently associated with operative mortality (odds ratio [OR] 2.88, 95% confidence interval [CI]: 2.0-4.5), pulmonary morbidity (OR 2.33, 95% CI: 1.93-2.8), and prolonged hospital stay (OR 2.73, 95% CI: 2.17-3.45). Low FEV1 was independently associated with pulmonary morbidity and prolonged hospital stay. Low PaO2 and DLCO were independently associated with a combined mortality and pulmonary morbidity endpoint. CONCLUSIONS: CLD is associated with adverse operative outcomes in selected patients with aortic stenosis undergoing AVR. FEV1, DLCO, and PaO2 may add important information to current risk adjustment models beyond the broad CLD classification.

Duke Scholars

Published In

Ann Thorac Surg

DOI

EISSN

1552-6259

Publication Date

December 2014

Volume

98

Issue

6

Start / End Page

2068 / 2077

Location

Netherlands

Related Subject Headings

  • United States
  • Treatment Outcome
  • Time Factors
  • Survival Rate
  • Severity of Illness Index
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Respiratory System
  • Respiratory Function Tests
 

Citation

APA
Chicago
ICMJE
MLA
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Crestanello, J. A., Higgins, R. S. D., He, X., Saha-Chaudhuri, P., Englum, B. R., Brennan, J. M., & Thourani, V. H. (2014). The association of chronic lung disease with early mortality and respiratory adverse events after aortic valve replacement. Ann Thorac Surg, 98(6), 2068–2077. https://doi.org/10.1016/j.athoracsur.2014.06.087
Crestanello, Juan A., Robert S. D. Higgins, Xia He, Paramita Saha-Chaudhuri, Brian R. Englum, J Matthew Brennan, and Vinod H. Thourani. “The association of chronic lung disease with early mortality and respiratory adverse events after aortic valve replacement.Ann Thorac Surg 98, no. 6 (December 2014): 2068–77. https://doi.org/10.1016/j.athoracsur.2014.06.087.
Crestanello JA, Higgins RSD, He X, Saha-Chaudhuri P, Englum BR, Brennan JM, et al. The association of chronic lung disease with early mortality and respiratory adverse events after aortic valve replacement. Ann Thorac Surg. 2014 Dec;98(6):2068–77.
Crestanello, Juan A., et al. “The association of chronic lung disease with early mortality and respiratory adverse events after aortic valve replacement.Ann Thorac Surg, vol. 98, no. 6, Dec. 2014, pp. 2068–77. Pubmed, doi:10.1016/j.athoracsur.2014.06.087.
Crestanello JA, Higgins RSD, He X, Saha-Chaudhuri P, Englum BR, Brennan JM, Thourani VH. The association of chronic lung disease with early mortality and respiratory adverse events after aortic valve replacement. Ann Thorac Surg. 2014 Dec;98(6):2068–2077.
Journal cover image

Published In

Ann Thorac Surg

DOI

EISSN

1552-6259

Publication Date

December 2014

Volume

98

Issue

6

Start / End Page

2068 / 2077

Location

Netherlands

Related Subject Headings

  • United States
  • Treatment Outcome
  • Time Factors
  • Survival Rate
  • Severity of Illness Index
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Respiratory System
  • Respiratory Function Tests