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Improving outcomes in advanced DLBCL: systemic approaches and radiotherapy.

Publication ,  Journal Article
Boyle, J; Beaven, AW; Diehl, LF; Prosnitz, LR; Kelsey, CR
Published in: Oncology (Williston Park)
December 2014

Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma. Approximately half of patients will present with advanced (stage III/IV) disease. The cornerstone of treatment is a combination of chemotherapy and immunotherapy, most commonly R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone). Efforts to improve upon R-CHOP-including more chemotherapy cycles, dose-dense chemotherapy, alternative drug combinations, high-dose chemotherapy with autologous stem cell transplant, and maintenance rituximab-have generally proved unsuccessful. There is a growing body of retrospective and prospective data, however, suggesting a benefit for consolidation radiation therapy (RT) in select patients with advanced DLBCL. Consolidation RT has been shown to improve outcomes for patients with advanced DLBCL generally, and in specific instances including initially bulky disease, bone involvement, or in the setting of a partial response to systemic therapy. In these settings consolidation RT is highly efficacious at achieving local disease control and improving overall outcomes.

Duke Scholars

Published In

Oncology (Williston Park)

ISSN

0890-9091

Publication Date

December 2014

Volume

28

Issue

12

Start / End Page

1074 / 1084

Location

United States

Related Subject Headings

  • Vincristine
  • Treatment Outcome
  • Survival Rate
  • Rituximab
  • Radiotherapy
  • Prednisone
  • Positron-Emission Tomography
  • Patient Outcome Assessment
  • Lymphoma, Large B-Cell, Diffuse
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Boyle, J., Beaven, A. W., Diehl, L. F., Prosnitz, L. R., & Kelsey, C. R. (2014). Improving outcomes in advanced DLBCL: systemic approaches and radiotherapy. Oncology (Williston Park), 28(12), 1074–1084.
Boyle, John, Anne W. Beaven, Louis F. Diehl, Leonard R. Prosnitz, and Chris R. Kelsey. “Improving outcomes in advanced DLBCL: systemic approaches and radiotherapy.Oncology (Williston Park) 28, no. 12 (December 2014): 1074–84.
Boyle J, Beaven AW, Diehl LF, Prosnitz LR, Kelsey CR. Improving outcomes in advanced DLBCL: systemic approaches and radiotherapy. Oncology (Williston Park). 2014 Dec;28(12):1074–84.
Boyle, John, et al. “Improving outcomes in advanced DLBCL: systemic approaches and radiotherapy.Oncology (Williston Park), vol. 28, no. 12, Dec. 2014, pp. 1074–84.
Boyle J, Beaven AW, Diehl LF, Prosnitz LR, Kelsey CR. Improving outcomes in advanced DLBCL: systemic approaches and radiotherapy. Oncology (Williston Park). 2014 Dec;28(12):1074–1084.

Published In

Oncology (Williston Park)

ISSN

0890-9091

Publication Date

December 2014

Volume

28

Issue

12

Start / End Page

1074 / 1084

Location

United States

Related Subject Headings

  • Vincristine
  • Treatment Outcome
  • Survival Rate
  • Rituximab
  • Radiotherapy
  • Prednisone
  • Positron-Emission Tomography
  • Patient Outcome Assessment
  • Lymphoma, Large B-Cell, Diffuse
  • Humans